A novel drug discovery strategy: Mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways

The p53 and nuclear factor κB (NF-κB) pathways play crucial roles in human cancer development. Simultaneous targeting of both pathways is an attractive therapeutic strategy against cancer. In this study, we report an antitumor molecule that bears a pyrrolo[3,4-c]pyrazole scaffold and functions as an...

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Detalles Bibliográficos
Autores principales: Zhuang, Chunlin, Sheng, Chunquan, Shin, Woo Shik, Wu, Yuelin, Li, Jin, Yao, Jianzhong, Dong, Guoqiang, Zhang, Wen, Sham, Yuk Yin, Miao, Zhenyuan, Zhang, Wannian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279413/
https://www.ncbi.nlm.nih.gov/pubmed/25350970

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