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Evaluation of silica nanoparticle toxicity after topical exposure for 90 days
Silica is a very common material that can be found in both crystalline and amorphous forms. Well-known toxicities of the lung can occur after exposure to the crystalline form of silica. However, the toxicities of the amorphous form of silica have not been thoroughly studied. The majority of in vivo...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279761/ https://www.ncbi.nlm.nih.gov/pubmed/25565831 http://dx.doi.org/10.2147/IJN.S57929 |
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author | Ryu, Hwa Jung Seong, Nak-won So, Byoung Joon Seo, Heung-sik Kim, Jun-ho Hong, Jeong-Sup Park, Myeong-kyu Kim, Min-Seok Kim, Yu-Ri Cho, Kyu-Bong Seo, Mu Yeb Kim, Meyoung-Kon Maeng, Eun Ho Son, Sang Wook |
author_facet | Ryu, Hwa Jung Seong, Nak-won So, Byoung Joon Seo, Heung-sik Kim, Jun-ho Hong, Jeong-Sup Park, Myeong-kyu Kim, Min-Seok Kim, Yu-Ri Cho, Kyu-Bong Seo, Mu Yeb Kim, Meyoung-Kon Maeng, Eun Ho Son, Sang Wook |
author_sort | Ryu, Hwa Jung |
collection | PubMed |
description | Silica is a very common material that can be found in both crystalline and amorphous forms. Well-known toxicities of the lung can occur after exposure to the crystalline form of silica. However, the toxicities of the amorphous form of silica have not been thoroughly studied. The majority of in vivo studies of amorphous silica nanoparticles (NPs) were performed using an inhalation exposure method. Since silica NPs can be commonly administered through the skin, a study of dermal silica toxicity was necessary to determine any harmful effects from dermal exposures. The present study focused on the results of systemic toxicity after applying 20 nm colloidal silica NPs on rat skin for 90 days, in accordance with the Organization for Economic Cooperation and Development test guideline 411 with a good laboratory practice system. Unlike the inhalation route or gastrointestinal route, the contact of silica NPs through skin did not result in any toxicity or any change in internal organs up to a dose of 2,000 mg/kg in rats. |
format | Online Article Text |
id | pubmed-4279761 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-42797612015-01-06 Evaluation of silica nanoparticle toxicity after topical exposure for 90 days Ryu, Hwa Jung Seong, Nak-won So, Byoung Joon Seo, Heung-sik Kim, Jun-ho Hong, Jeong-Sup Park, Myeong-kyu Kim, Min-Seok Kim, Yu-Ri Cho, Kyu-Bong Seo, Mu Yeb Kim, Meyoung-Kon Maeng, Eun Ho Son, Sang Wook Int J Nanomedicine Original Research Silica is a very common material that can be found in both crystalline and amorphous forms. Well-known toxicities of the lung can occur after exposure to the crystalline form of silica. However, the toxicities of the amorphous form of silica have not been thoroughly studied. The majority of in vivo studies of amorphous silica nanoparticles (NPs) were performed using an inhalation exposure method. Since silica NPs can be commonly administered through the skin, a study of dermal silica toxicity was necessary to determine any harmful effects from dermal exposures. The present study focused on the results of systemic toxicity after applying 20 nm colloidal silica NPs on rat skin for 90 days, in accordance with the Organization for Economic Cooperation and Development test guideline 411 with a good laboratory practice system. Unlike the inhalation route or gastrointestinal route, the contact of silica NPs through skin did not result in any toxicity or any change in internal organs up to a dose of 2,000 mg/kg in rats. Dove Medical Press 2014-12-15 /pmc/articles/PMC4279761/ /pubmed/25565831 http://dx.doi.org/10.2147/IJN.S57929 Text en © 2014 Ryu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Ryu, Hwa Jung Seong, Nak-won So, Byoung Joon Seo, Heung-sik Kim, Jun-ho Hong, Jeong-Sup Park, Myeong-kyu Kim, Min-Seok Kim, Yu-Ri Cho, Kyu-Bong Seo, Mu Yeb Kim, Meyoung-Kon Maeng, Eun Ho Son, Sang Wook Evaluation of silica nanoparticle toxicity after topical exposure for 90 days |
title | Evaluation of silica nanoparticle toxicity after topical exposure for 90 days |
title_full | Evaluation of silica nanoparticle toxicity after topical exposure for 90 days |
title_fullStr | Evaluation of silica nanoparticle toxicity after topical exposure for 90 days |
title_full_unstemmed | Evaluation of silica nanoparticle toxicity after topical exposure for 90 days |
title_short | Evaluation of silica nanoparticle toxicity after topical exposure for 90 days |
title_sort | evaluation of silica nanoparticle toxicity after topical exposure for 90 days |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279761/ https://www.ncbi.nlm.nih.gov/pubmed/25565831 http://dx.doi.org/10.2147/IJN.S57929 |
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