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Preliminary report: neural firing patterns specific for Meniere’s disease

OBJECTIVE: To describe the application of a new, objective diagnostic test for Meniere’s disease. INTRODUCTION: Electrovestibulography (EVestG) is a complex, newly-developed test paradigm that searches for neural firing patterns that may be diagnostic for particular neural disorders. EVestG system w...

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Autores principales: Blakley, Brian, Dastgheib, Zeinab A, Lithgow, Brian, Moussavi, Zahra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279806/
https://www.ncbi.nlm.nih.gov/pubmed/25526745
http://dx.doi.org/10.1186/s40463-014-0052-4
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author Blakley, Brian
Dastgheib, Zeinab A
Lithgow, Brian
Moussavi, Zahra
author_facet Blakley, Brian
Dastgheib, Zeinab A
Lithgow, Brian
Moussavi, Zahra
author_sort Blakley, Brian
collection PubMed
description OBJECTIVE: To describe the application of a new, objective diagnostic test for Meniere’s disease. INTRODUCTION: Electrovestibulography (EVestG) is a complex, newly-developed test paradigm that searches for neural firing patterns that may be diagnostic for particular neural disorders. EVestG system was previously “trained” to distinguish Meniere’s disease from other patients on a set of training data. In this paper we illustrate its diagnostic application in a new group of unknown subjects. SETTING: Collaborative Academic Bioengineering Research Centre. STUDY DESIGN: Prospective, blinded human Clinical Trial. METHODS: In an attempt to understand the specific neural firing patterns that may objectively characterize latent Meniere’s disease, two hundred fifty-six consecutive patients who presented for electronystagmography testing were asked to undergo EVestG testing. Ten subjects actually completed testing but data were too noisy to permit analysis for one patient. Complete data were available for nine patients with either a clinical diagnosis of either Meniere’s disease (4 patients) or some other vestibular disorder (2 vestibular neuritis, 2 benign positional vertigo and 1 non-specific dizziness). None of the patients were experiencing attacks of vertigo within a week of EVestG testing. Ten normal control subjects with no history or symptoms of ear disease were also tested. EVestG was performed in a separate engineering research facility by investigators who were unaware of their clinical diagnosis. If EVestG suggested that the probability of Meniere’s disease was 0.5 or greater Meniere’s disease was considered present by the objective testing. The objective and clinical diagnoses were compared. RESULTS: EVestG testing correctly identified three of four Meniere’s disease patients and rejected the diagnosis in 9 of the 10 controls. Two of the 5 dizzy, non-Meniere’s patients were incorrectly identified as Meniere’s disease. The sensitivity and specificity of EvestG testing were 75% and 80%, respectively. EVestG results were statistically significantly different for Meniere’s patients versus the other dizzy patients and controls (Univariate ANOVA difference contrasts p = 0.0340) even in this small sample. CONCLUSION: The EVestG protocol appeared to show promise as an objective, diagnostic test for Meniere’s disease, but our sample size is too small to generalize widely. LEVEL OF EVIDENCE: N.A. Prospective Human clinical trial.
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spelling pubmed-42798062014-12-31 Preliminary report: neural firing patterns specific for Meniere’s disease Blakley, Brian Dastgheib, Zeinab A Lithgow, Brian Moussavi, Zahra J Otolaryngol Head Neck Surg Original Research Article OBJECTIVE: To describe the application of a new, objective diagnostic test for Meniere’s disease. INTRODUCTION: Electrovestibulography (EVestG) is a complex, newly-developed test paradigm that searches for neural firing patterns that may be diagnostic for particular neural disorders. EVestG system was previously “trained” to distinguish Meniere’s disease from other patients on a set of training data. In this paper we illustrate its diagnostic application in a new group of unknown subjects. SETTING: Collaborative Academic Bioengineering Research Centre. STUDY DESIGN: Prospective, blinded human Clinical Trial. METHODS: In an attempt to understand the specific neural firing patterns that may objectively characterize latent Meniere’s disease, two hundred fifty-six consecutive patients who presented for electronystagmography testing were asked to undergo EVestG testing. Ten subjects actually completed testing but data were too noisy to permit analysis for one patient. Complete data were available for nine patients with either a clinical diagnosis of either Meniere’s disease (4 patients) or some other vestibular disorder (2 vestibular neuritis, 2 benign positional vertigo and 1 non-specific dizziness). None of the patients were experiencing attacks of vertigo within a week of EVestG testing. Ten normal control subjects with no history or symptoms of ear disease were also tested. EVestG was performed in a separate engineering research facility by investigators who were unaware of their clinical diagnosis. If EVestG suggested that the probability of Meniere’s disease was 0.5 or greater Meniere’s disease was considered present by the objective testing. The objective and clinical diagnoses were compared. RESULTS: EVestG testing correctly identified three of four Meniere’s disease patients and rejected the diagnosis in 9 of the 10 controls. Two of the 5 dizzy, non-Meniere’s patients were incorrectly identified as Meniere’s disease. The sensitivity and specificity of EvestG testing were 75% and 80%, respectively. EVestG results were statistically significantly different for Meniere’s patients versus the other dizzy patients and controls (Univariate ANOVA difference contrasts p = 0.0340) even in this small sample. CONCLUSION: The EVestG protocol appeared to show promise as an objective, diagnostic test for Meniere’s disease, but our sample size is too small to generalize widely. LEVEL OF EVIDENCE: N.A. Prospective Human clinical trial. BioMed Central 2014-12-20 /pmc/articles/PMC4279806/ /pubmed/25526745 http://dx.doi.org/10.1186/s40463-014-0052-4 Text en © Blakley et al.; licensee BioMed Central. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Original Research Article
Blakley, Brian
Dastgheib, Zeinab A
Lithgow, Brian
Moussavi, Zahra
Preliminary report: neural firing patterns specific for Meniere’s disease
title Preliminary report: neural firing patterns specific for Meniere’s disease
title_full Preliminary report: neural firing patterns specific for Meniere’s disease
title_fullStr Preliminary report: neural firing patterns specific for Meniere’s disease
title_full_unstemmed Preliminary report: neural firing patterns specific for Meniere’s disease
title_short Preliminary report: neural firing patterns specific for Meniere’s disease
title_sort preliminary report: neural firing patterns specific for meniere’s disease
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279806/
https://www.ncbi.nlm.nih.gov/pubmed/25526745
http://dx.doi.org/10.1186/s40463-014-0052-4
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