Renal thromboembolism during treatment with recombinant activated factor VII (rFVIIa) in a child with hemophilia B with factor IX inhibitors

BACKGROUND: Serious thromboembolic events connected with rFVIIa therapy in hemophilia patients are rare. Only three cases are reported in children, all of them with hemophilia A. CASE PRESENTATION: We present unique case of patient with hemophilia B and high titer inhibitors to coagulation FIX, who...

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Autores principales: Milošević, Danko, Bilić, Ernest, Batinić, Danica, Poropat, Mirjana, Štern-Padovan, Ranka, Galić, Slobodan, Turudić, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279815/
https://www.ncbi.nlm.nih.gov/pubmed/25515020
http://dx.doi.org/10.1186/s12887-014-0315-2
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author Milošević, Danko
Bilić, Ernest
Batinić, Danica
Poropat, Mirjana
Štern-Padovan, Ranka
Galić, Slobodan
Turudić, Daniel
author_facet Milošević, Danko
Bilić, Ernest
Batinić, Danica
Poropat, Mirjana
Štern-Padovan, Ranka
Galić, Slobodan
Turudić, Daniel
author_sort Milošević, Danko
collection PubMed
description BACKGROUND: Serious thromboembolic events connected with rFVIIa therapy in hemophilia patients are rare. Only three cases are reported in children, all of them with hemophilia A. CASE PRESENTATION: We present unique case of patient with hemophilia B and high titer inhibitors to coagulation FIX, who developed severe renal damage due to thromboembolic event during rFVIIa therapy, associated with unsuspected renovascular anomalies. CONCLUSION: Caution is necessary if hematuria B requires administration of rFVIIa. US color doppler renal imaging before and after drug administration should be sufficient as an early warning.
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spelling pubmed-42798152014-12-31 Renal thromboembolism during treatment with recombinant activated factor VII (rFVIIa) in a child with hemophilia B with factor IX inhibitors Milošević, Danko Bilić, Ernest Batinić, Danica Poropat, Mirjana Štern-Padovan, Ranka Galić, Slobodan Turudić, Daniel BMC Pediatr Case Report BACKGROUND: Serious thromboembolic events connected with rFVIIa therapy in hemophilia patients are rare. Only three cases are reported in children, all of them with hemophilia A. CASE PRESENTATION: We present unique case of patient with hemophilia B and high titer inhibitors to coagulation FIX, who developed severe renal damage due to thromboembolic event during rFVIIa therapy, associated with unsuspected renovascular anomalies. CONCLUSION: Caution is necessary if hematuria B requires administration of rFVIIa. US color doppler renal imaging before and after drug administration should be sufficient as an early warning. BioMed Central 2014-12-17 /pmc/articles/PMC4279815/ /pubmed/25515020 http://dx.doi.org/10.1186/s12887-014-0315-2 Text en © Milosevic et al.; licensee BioMed Central. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Milošević, Danko
Bilić, Ernest
Batinić, Danica
Poropat, Mirjana
Štern-Padovan, Ranka
Galić, Slobodan
Turudić, Daniel
Renal thromboembolism during treatment with recombinant activated factor VII (rFVIIa) in a child with hemophilia B with factor IX inhibitors
title Renal thromboembolism during treatment with recombinant activated factor VII (rFVIIa) in a child with hemophilia B with factor IX inhibitors
title_full Renal thromboembolism during treatment with recombinant activated factor VII (rFVIIa) in a child with hemophilia B with factor IX inhibitors
title_fullStr Renal thromboembolism during treatment with recombinant activated factor VII (rFVIIa) in a child with hemophilia B with factor IX inhibitors
title_full_unstemmed Renal thromboembolism during treatment with recombinant activated factor VII (rFVIIa) in a child with hemophilia B with factor IX inhibitors
title_short Renal thromboembolism during treatment with recombinant activated factor VII (rFVIIa) in a child with hemophilia B with factor IX inhibitors
title_sort renal thromboembolism during treatment with recombinant activated factor vii (rfviia) in a child with hemophilia b with factor ix inhibitors
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279815/
https://www.ncbi.nlm.nih.gov/pubmed/25515020
http://dx.doi.org/10.1186/s12887-014-0315-2
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