Melatonin as a potential therapy for sepsis: a phase I dose escalation study and an ex vivo whole blood model under conditions of sepsis

Sepsis is a massive inflammatory response mediated by infection, characterized by oxidative stress, release of cytokines, and mitochondrial dysfunction. Melatonin accumulates in mitochondria, and both it and its metabolites have potent antioxidant and anti-inflammatory activities and may be useful i...

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Detalles Bibliográficos
Autores principales: Galley, Helen F, Lowes, Damon A, Allen, Lee, Cameron, Gary, Aucott, Lorna S, Webster, Nigel R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279949/
https://www.ncbi.nlm.nih.gov/pubmed/24650045
http://dx.doi.org/10.1111/jpi.12134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279949/
https://www.ncbi.nlm.nih.gov/pubmed/24650045
http://dx.doi.org/10.1111/jpi.12134

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