Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer’s disease early phenotypes

BACKGROUND: It is suspected that excess of brain cholesterol plays a role in Alzheimer’s disease (AD). Membrane-associated cholesterol was shown to be increased in the brain of individuals with sporadic AD and to correlate with the severity of the disease. We hypothesized that an increase of membran...

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Detalles Bibliográficos
Autores principales: Marquer, Catherine, Laine, Jeanne, Dauphinot, Luce, Hanbouch, Linda, Lemercier-Neuillet, Camille, Pierrot, Nathalie, Bossers, Koen, Le, Mickael, Corlier, Fabian, Benstaali, Caroline, Saudou, Frédéric, Thinakaran, Gopal, Cartier, Nathalie, Octave, Jean-Noël, Duyckaerts, Charles, Potier, Marie-Claude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280040/
https://www.ncbi.nlm.nih.gov/pubmed/25524049
http://dx.doi.org/10.1186/1750-1326-9-60

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