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Liposomal Spherical Nucleic Acids
[Image: see text] A novel class of metal-free spherical nucleic acid nanostructures was synthesized from readily available starting components. These particles consist of 30 nm liposomal cores, composed of an FDA-approved 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) lipid monomer. The surface of...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280063/ https://www.ncbi.nlm.nih.gov/pubmed/24983505 http://dx.doi.org/10.1021/ja504845f |
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author | Banga, Resham J. Chernyak, Natalia Narayan, Suguna P. Nguyen, SonBinh T. Mirkin, Chad A. |
author_facet | Banga, Resham J. Chernyak, Natalia Narayan, Suguna P. Nguyen, SonBinh T. Mirkin, Chad A. |
author_sort | Banga, Resham J. |
collection | PubMed |
description | [Image: see text] A novel class of metal-free spherical nucleic acid nanostructures was synthesized from readily available starting components. These particles consist of 30 nm liposomal cores, composed of an FDA-approved 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) lipid monomer. The surface of the liposomes was functionalized with DNA strands modified with a tocopherol tail that intercalates into the phospholipid layer of the liposomal core via hydrophobic interactions. The spherical nucleic acid architecture not only stabilizes these constructs but also facilitates cellular internalization and gene regulation in SKOV-3 cells. |
format | Online Article Text |
id | pubmed-4280063 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | American Chemical
Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-42800632015-07-01 Liposomal Spherical Nucleic Acids Banga, Resham J. Chernyak, Natalia Narayan, Suguna P. Nguyen, SonBinh T. Mirkin, Chad A. J Am Chem Soc [Image: see text] A novel class of metal-free spherical nucleic acid nanostructures was synthesized from readily available starting components. These particles consist of 30 nm liposomal cores, composed of an FDA-approved 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) lipid monomer. The surface of the liposomes was functionalized with DNA strands modified with a tocopherol tail that intercalates into the phospholipid layer of the liposomal core via hydrophobic interactions. The spherical nucleic acid architecture not only stabilizes these constructs but also facilitates cellular internalization and gene regulation in SKOV-3 cells. American Chemical Society 2014-07-01 2014-07-16 /pmc/articles/PMC4280063/ /pubmed/24983505 http://dx.doi.org/10.1021/ja504845f Text en Copyright © 2014 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Banga, Resham J. Chernyak, Natalia Narayan, Suguna P. Nguyen, SonBinh T. Mirkin, Chad A. Liposomal Spherical Nucleic Acids |
title | Liposomal
Spherical Nucleic Acids |
title_full | Liposomal
Spherical Nucleic Acids |
title_fullStr | Liposomal
Spherical Nucleic Acids |
title_full_unstemmed | Liposomal
Spherical Nucleic Acids |
title_short | Liposomal
Spherical Nucleic Acids |
title_sort | liposomal
spherical nucleic acids |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280063/ https://www.ncbi.nlm.nih.gov/pubmed/24983505 http://dx.doi.org/10.1021/ja504845f |
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