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MiR-29a Reduces TIMP-1 Production by Dermal Fibroblasts via Targeting TGF-β Activated Kinase 1 Binding Protein 1, Implications for Systemic Sclerosis

BACKGROUND: Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterised by skin and internal organs fibrosis due to accumulation of extra cellular matrix (ECM) proteins. Tissue inhibitor of metalloproteinases 1 (TIMP-1) plays a key role in ECM deposition. AIM: To investigate th...

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Detalles Bibliográficos
Autores principales:	Ciechomska, Marzena, O’Reilly, Steven, Suwara, Monika, Bogunia-Kubik, Katarzyna, van Laar, Jacob M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280195/ https://www.ncbi.nlm.nih.gov/pubmed/25549087 http://dx.doi.org/10.1371/journal.pone.0115596

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