Cargando…
Results availability for analgesic device, complex regional pain syndrome, and post-stroke pain trials: comparing the RReADS, RReACT, and RReMiT databases
Evidence-based medicine rests on the assumption that treatment recommendations are robust, free from bias, and include results of all randomized clinical trials. The Repository of Registered Analgesic Clinical Trials search and analysis methodology was applied to create databases of complex regional...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280280/ https://www.ncbi.nlm.nih.gov/pubmed/25599303 http://dx.doi.org/10.1016/j.pain.0000000000000009 |
_version_ | 1782350832262447104 |
---|---|
author | Dufka, Faustine L. Munch, Troels Dworkin, Robert H. Rowbotham, Michael C. |
author_facet | Dufka, Faustine L. Munch, Troels Dworkin, Robert H. Rowbotham, Michael C. |
author_sort | Dufka, Faustine L. |
collection | PubMed |
description | Evidence-based medicine rests on the assumption that treatment recommendations are robust, free from bias, and include results of all randomized clinical trials. The Repository of Registered Analgesic Clinical Trials search and analysis methodology was applied to create databases of complex regional pain syndrome (CRPS) and central post-stroke pain (CPSP) trials and adapted to create the Repository of Registered Analgesic Device Studies databases for trials of spinal cord stimulation (SCS), repetitive transcranial magnetic stimulation (rTMS), and transcranial direct current stimulation (tDCS). We identified 34 CRPS trials, 18 CPSP trials, 72 trials of SCS, and 92 trials of rTMS/tDCS. Irrespective of time since study completion, 45% of eligible CRPS and CPSP trials and 46% of eligible SCS and rTMS/tDCS trials had available results (peer-reviewed literature, results entered on registry, or gray literature); peer-reviewed publications could be found for 38% and 39%, respectively. Examining almost 1000 trials across a spectrum of painful disorders (fibromyalgia, diabetic painful neuropathy, post-herpetic neuralgia, migraine, CRPS, CPSP) and types of treatment, no single study characteristic consistently predicts unavailability of results. Results availability is higher 12 months after study completion but remains below 60% for peer-reviewed publications. Recommendations to increase results availability include supporting organizations advocating for transparency, enforcing existing results reporting regulations, enabling all primary registries to post results, stating trial registration numbers in all publication abstracts, and reducing barriers to publishing “negative” trials. For all diseases and treatment modalities, evidence-based medicine must rigorously adjust for the sheer magnitude of missing results in formulating treatment recommendations. |
format | Online Article Text |
id | pubmed-4280280 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Wolters Kluwer |
record_format | MEDLINE/PubMed |
spelling | pubmed-42802802015-01-06 Results availability for analgesic device, complex regional pain syndrome, and post-stroke pain trials: comparing the RReADS, RReACT, and RReMiT databases Dufka, Faustine L. Munch, Troels Dworkin, Robert H. Rowbotham, Michael C. Pain Research Paper Evidence-based medicine rests on the assumption that treatment recommendations are robust, free from bias, and include results of all randomized clinical trials. The Repository of Registered Analgesic Clinical Trials search and analysis methodology was applied to create databases of complex regional pain syndrome (CRPS) and central post-stroke pain (CPSP) trials and adapted to create the Repository of Registered Analgesic Device Studies databases for trials of spinal cord stimulation (SCS), repetitive transcranial magnetic stimulation (rTMS), and transcranial direct current stimulation (tDCS). We identified 34 CRPS trials, 18 CPSP trials, 72 trials of SCS, and 92 trials of rTMS/tDCS. Irrespective of time since study completion, 45% of eligible CRPS and CPSP trials and 46% of eligible SCS and rTMS/tDCS trials had available results (peer-reviewed literature, results entered on registry, or gray literature); peer-reviewed publications could be found for 38% and 39%, respectively. Examining almost 1000 trials across a spectrum of painful disorders (fibromyalgia, diabetic painful neuropathy, post-herpetic neuralgia, migraine, CRPS, CPSP) and types of treatment, no single study characteristic consistently predicts unavailability of results. Results availability is higher 12 months after study completion but remains below 60% for peer-reviewed publications. Recommendations to increase results availability include supporting organizations advocating for transparency, enforcing existing results reporting regulations, enabling all primary registries to post results, stating trial registration numbers in all publication abstracts, and reducing barriers to publishing “negative” trials. For all diseases and treatment modalities, evidence-based medicine must rigorously adjust for the sheer magnitude of missing results in formulating treatment recommendations. Wolters Kluwer 2015-01 2014-12-17 /pmc/articles/PMC4280280/ /pubmed/25599303 http://dx.doi.org/10.1016/j.pain.0000000000000009 Text en © 2014 International Association for the Study of Pain This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial No Derivitives 3.0 License, which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially. |
spellingShingle | Research Paper Dufka, Faustine L. Munch, Troels Dworkin, Robert H. Rowbotham, Michael C. Results availability for analgesic device, complex regional pain syndrome, and post-stroke pain trials: comparing the RReADS, RReACT, and RReMiT databases |
title | Results availability for analgesic device, complex regional pain syndrome, and post-stroke pain trials: comparing the RReADS, RReACT, and RReMiT databases |
title_full | Results availability for analgesic device, complex regional pain syndrome, and post-stroke pain trials: comparing the RReADS, RReACT, and RReMiT databases |
title_fullStr | Results availability for analgesic device, complex regional pain syndrome, and post-stroke pain trials: comparing the RReADS, RReACT, and RReMiT databases |
title_full_unstemmed | Results availability for analgesic device, complex regional pain syndrome, and post-stroke pain trials: comparing the RReADS, RReACT, and RReMiT databases |
title_short | Results availability for analgesic device, complex regional pain syndrome, and post-stroke pain trials: comparing the RReADS, RReACT, and RReMiT databases |
title_sort | results availability for analgesic device, complex regional pain syndrome, and post-stroke pain trials: comparing the rreads, rreact, and rremit databases |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280280/ https://www.ncbi.nlm.nih.gov/pubmed/25599303 http://dx.doi.org/10.1016/j.pain.0000000000000009 |
work_keys_str_mv | AT dufkafaustinel resultsavailabilityforanalgesicdevicecomplexregionalpainsyndromeandpoststrokepaintrialscomparingtherreadsrreactandrremitdatabases AT munchtroels resultsavailabilityforanalgesicdevicecomplexregionalpainsyndromeandpoststrokepaintrialscomparingtherreadsrreactandrremitdatabases AT dworkinroberth resultsavailabilityforanalgesicdevicecomplexregionalpainsyndromeandpoststrokepaintrialscomparingtherreadsrreactandrremitdatabases AT rowbothammichaelc resultsavailabilityforanalgesicdevicecomplexregionalpainsyndromeandpoststrokepaintrialscomparingtherreadsrreactandrremitdatabases |