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Chest Wall Pain as the Presenting Symptom of Leptomeningeal Carcinomatosis
Leptomeningeal metastasis (LMM), also referred to as leptomeningeal carcinomatosis, results from diffuse infiltration of the leptomeninges by malignant cells originating from extra-meningeal primary tumors. It occurs in approximately 5%-10% of patients with solid tumor. Among solid tumors, the most...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Academy of Rehabilitation Medicine
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280386/ https://www.ncbi.nlm.nih.gov/pubmed/25566489 http://dx.doi.org/10.5535/arm.2014.38.6.861 |
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author | Sim, Kyoung Bo Nam, Ki Yeun Lee, Ho Jun Park, Jin-Woo Ryu, Gi Hyeong Chang, Jihea Kwon, Bum Sun |
author_facet | Sim, Kyoung Bo Nam, Ki Yeun Lee, Ho Jun Park, Jin-Woo Ryu, Gi Hyeong Chang, Jihea Kwon, Bum Sun |
author_sort | Sim, Kyoung Bo |
collection | PubMed |
description | Leptomeningeal metastasis (LMM), also referred to as leptomeningeal carcinomatosis, results from diffuse infiltration of the leptomeninges by malignant cells originating from extra-meningeal primary tumors. It occurs in approximately 5%-10% of patients with solid tumor. Among solid tumors, the most common types leading to infiltration of the leptomeninges are breast cancer, lung cancer, and melanoma. Patients with LMM may present various signs and symptoms. Herein, we report a rare case with initial presentation of isolated chest wall pain. Computed tomography of the chest with contrast revealed a 2.5-cm nodule over the left upper lung. Biopsy confirmed the diagnosis of adenocarcinoma. Later, cerebrospinal fluid cytology exam also confirmed leptomeningeal seeding. It is rare for leptomeningeal carcinomatosis patients to present with chest wall pain. Therefore, a high index of suspicion is mandatory for accurate and prompt diagnosis. |
format | Online Article Text |
id | pubmed-4280386 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Korean Academy of Rehabilitation Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-42803862015-01-06 Chest Wall Pain as the Presenting Symptom of Leptomeningeal Carcinomatosis Sim, Kyoung Bo Nam, Ki Yeun Lee, Ho Jun Park, Jin-Woo Ryu, Gi Hyeong Chang, Jihea Kwon, Bum Sun Ann Rehabil Med Case Report Leptomeningeal metastasis (LMM), also referred to as leptomeningeal carcinomatosis, results from diffuse infiltration of the leptomeninges by malignant cells originating from extra-meningeal primary tumors. It occurs in approximately 5%-10% of patients with solid tumor. Among solid tumors, the most common types leading to infiltration of the leptomeninges are breast cancer, lung cancer, and melanoma. Patients with LMM may present various signs and symptoms. Herein, we report a rare case with initial presentation of isolated chest wall pain. Computed tomography of the chest with contrast revealed a 2.5-cm nodule over the left upper lung. Biopsy confirmed the diagnosis of adenocarcinoma. Later, cerebrospinal fluid cytology exam also confirmed leptomeningeal seeding. It is rare for leptomeningeal carcinomatosis patients to present with chest wall pain. Therefore, a high index of suspicion is mandatory for accurate and prompt diagnosis. Korean Academy of Rehabilitation Medicine 2014-12 2014-12-24 /pmc/articles/PMC4280386/ /pubmed/25566489 http://dx.doi.org/10.5535/arm.2014.38.6.861 Text en Copyright © 2014 by Korean Academy of Rehabilitation Medicine http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Sim, Kyoung Bo Nam, Ki Yeun Lee, Ho Jun Park, Jin-Woo Ryu, Gi Hyeong Chang, Jihea Kwon, Bum Sun Chest Wall Pain as the Presenting Symptom of Leptomeningeal Carcinomatosis |
title | Chest Wall Pain as the Presenting Symptom of Leptomeningeal Carcinomatosis |
title_full | Chest Wall Pain as the Presenting Symptom of Leptomeningeal Carcinomatosis |
title_fullStr | Chest Wall Pain as the Presenting Symptom of Leptomeningeal Carcinomatosis |
title_full_unstemmed | Chest Wall Pain as the Presenting Symptom of Leptomeningeal Carcinomatosis |
title_short | Chest Wall Pain as the Presenting Symptom of Leptomeningeal Carcinomatosis |
title_sort | chest wall pain as the presenting symptom of leptomeningeal carcinomatosis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280386/ https://www.ncbi.nlm.nih.gov/pubmed/25566489 http://dx.doi.org/10.5535/arm.2014.38.6.861 |
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