Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report

Background: Recent studies proposed GLUT12 to be a major glucose transporter involved in the glycolytic metabolism of cancer cells. Methods: GLUT12 expression was determined by immunohistochemistry in a selection of cancer cell lines and a tumour spheroid model. Results: GLUT12 expression was high i...

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Detalles Bibliográficos
Autores principales: Pujol-Gimenez, Jonai, de Heredia, Fátima Pérez, Idoate, Miguel Angel, Airley, Rachel, Lostao, María Pilar, Evans, Andrew Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2015
Materias:
Short Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280396/
https://www.ncbi.nlm.nih.gov/pubmed/25561978
http://dx.doi.org/10.7150/jca.10429
Descripción
Sumario:Background: Recent studies proposed GLUT12 to be a major glucose transporter involved in the glycolytic metabolism of cancer cells. Methods: GLUT12 expression was determined by immunohistochemistry in a selection of cancer cell lines and a tumour spheroid model. Results: GLUT12 expression was high in A549 and RH-36; low in HT29; and absent in NB-EB cancer cell lines. GLUT12 expression was located in the necrotic centre of HT29 spheroids, which is characterised by anaerobic metabolism. Conclusion: The data supports the involvement of GLUT12 in the glycolytic metabolism of cancer cells and therefore, its potential as a novel therapeutic target for cancer treatment.

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