Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report

Background: Recent studies proposed GLUT12 to be a major glucose transporter involved in the glycolytic metabolism of cancer cells. Methods: GLUT12 expression was determined by immunohistochemistry in a selection of cancer cell lines and a tumour spheroid model. Results: GLUT12 expression was high i...

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Autores principales: Pujol-Gimenez, Jonai, de Heredia, Fátima Pérez, Idoate, Miguel Angel, Airley, Rachel, Lostao, María Pilar, Evans, Andrew Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2015
Materias:
Short Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280396/
https://www.ncbi.nlm.nih.gov/pubmed/25561978
http://dx.doi.org/10.7150/jca.10429
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author Pujol-Gimenez, Jonai
de Heredia, Fátima Pérez
Idoate, Miguel Angel
Airley, Rachel
Lostao, María Pilar
Evans, Andrew Robert
author_facet Pujol-Gimenez, Jonai
de Heredia, Fátima Pérez
Idoate, Miguel Angel
Airley, Rachel
Lostao, María Pilar
Evans, Andrew Robert
author_sort Pujol-Gimenez, Jonai
collection PubMed
description Background: Recent studies proposed GLUT12 to be a major glucose transporter involved in the glycolytic metabolism of cancer cells. Methods: GLUT12 expression was determined by immunohistochemistry in a selection of cancer cell lines and a tumour spheroid model. Results: GLUT12 expression was high in A549 and RH-36; low in HT29; and absent in NB-EB cancer cell lines. GLUT12 expression was located in the necrotic centre of HT29 spheroids, which is characterised by anaerobic metabolism. Conclusion: The data supports the involvement of GLUT12 in the glycolytic metabolism of cancer cells and therefore, its potential as a novel therapeutic target for cancer treatment.
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spelling pubmed-42803962015-01-05 Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report Pujol-Gimenez, Jonai de Heredia, Fátima Pérez Idoate, Miguel Angel Airley, Rachel Lostao, María Pilar Evans, Andrew Robert J Cancer Short Research Communication Background: Recent studies proposed GLUT12 to be a major glucose transporter involved in the glycolytic metabolism of cancer cells. Methods: GLUT12 expression was determined by immunohistochemistry in a selection of cancer cell lines and a tumour spheroid model. Results: GLUT12 expression was high in A549 and RH-36; low in HT29; and absent in NB-EB cancer cell lines. GLUT12 expression was located in the necrotic centre of HT29 spheroids, which is characterised by anaerobic metabolism. Conclusion: The data supports the involvement of GLUT12 in the glycolytic metabolism of cancer cells and therefore, its potential as a novel therapeutic target for cancer treatment. Ivyspring International Publisher 2015-01-05 /pmc/articles/PMC4280396/ /pubmed/25561978 http://dx.doi.org/10.7150/jca.10429 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Short Research Communication
Pujol-Gimenez, Jonai
de Heredia, Fátima Pérez
Idoate, Miguel Angel
Airley, Rachel
Lostao, María Pilar
Evans, Andrew Robert
Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report
title Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report
title_full Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report
title_fullStr Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report
title_full_unstemmed Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report
title_short Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report
title_sort could glut12 be a potential therapeutic target in cancer treatment? a preliminary report
topic Short Research Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280396/
https://www.ncbi.nlm.nih.gov/pubmed/25561978
http://dx.doi.org/10.7150/jca.10429
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