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Robotic stereotactic body radiation therapy for liver-limited malignant tumors

INTRODUCTION: Stereotactic body radiotherapy (SBRT) is rapidly gaining favor as a new treatment modality for malignant liver tumors. Most of the studies have recruited patients with disseminated disease originating from the liver. This study focuses on disease limited to the liver. AIM: To perform a...

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Autores principales: Frączek, Mariusz, Sobocki, Jacek, Pędziwiatr, Katarzyna, Skrocki, Edward, Piotrkowicz, Norbert, Tyc-Szczepaniak, Dobromira, Korab-Chrzanowska, Elżbieta, Hevelke, Piotr, Krasnodębski, Maciej, Koszewski, Waldemar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280411/
https://www.ncbi.nlm.nih.gov/pubmed/25561987
http://dx.doi.org/10.5114/wiitm.2014.44258
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author Frączek, Mariusz
Sobocki, Jacek
Pędziwiatr, Katarzyna
Skrocki, Edward
Piotrkowicz, Norbert
Tyc-Szczepaniak, Dobromira
Korab-Chrzanowska, Elżbieta
Hevelke, Piotr
Krasnodębski, Maciej
Koszewski, Waldemar
author_facet Frączek, Mariusz
Sobocki, Jacek
Pędziwiatr, Katarzyna
Skrocki, Edward
Piotrkowicz, Norbert
Tyc-Szczepaniak, Dobromira
Korab-Chrzanowska, Elżbieta
Hevelke, Piotr
Krasnodębski, Maciej
Koszewski, Waldemar
author_sort Frączek, Mariusz
collection PubMed
description INTRODUCTION: Stereotactic body radiotherapy (SBRT) is rapidly gaining favor as a new treatment modality for malignant liver tumors. Most of the studies have recruited patients with disseminated disease originating from the liver. This study focuses on disease limited to the liver. AIM: To perform a retrospective analysis of all patients with liver tumors treated by robotic stereotactic body radiation therapy in a single center. MATERIAL AND METHODS: The study included 13 patients with 22 lesions. The inclusion criteria were: patients with 1–4 inoperable liver lesions and absence of any extrahepatic disease. All but 3 patients received 3 fractions delivered by the Cyberknife system of a total of 45 grey (Gy). The other 3 patients received 30 Gy. RESULTS: The median follow-up time was 10.8 months (range: 7–16). The median dose was 41.5 Gy (range: 30–45). One lesion regressed (8%). In 5 patients, the disease was locally stabilized (38%), and in 7 other patients progression occurred (54%). Twelve patients (92%) are still alive, and 1 patient (8%) died. In 1 patient a new cancer (leukemia) was diagnosed. CONCLUSIONS: The SBRT is well tolerated and effective for local control of most liver malignant tumors. It appears that SBRT is best suited for those patients in whom systemic recurrence can be controlled by chemotherapy. Further studies are mandatory to elucidate these effects on tumors of varying histology and to elaborate upon criteria used to select patients who can benefit most from this treatment.
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spelling pubmed-42804112015-01-05 Robotic stereotactic body radiation therapy for liver-limited malignant tumors Frączek, Mariusz Sobocki, Jacek Pędziwiatr, Katarzyna Skrocki, Edward Piotrkowicz, Norbert Tyc-Szczepaniak, Dobromira Korab-Chrzanowska, Elżbieta Hevelke, Piotr Krasnodębski, Maciej Koszewski, Waldemar Wideochir Inne Tech Maloinwazyjne Original Paper INTRODUCTION: Stereotactic body radiotherapy (SBRT) is rapidly gaining favor as a new treatment modality for malignant liver tumors. Most of the studies have recruited patients with disseminated disease originating from the liver. This study focuses on disease limited to the liver. AIM: To perform a retrospective analysis of all patients with liver tumors treated by robotic stereotactic body radiation therapy in a single center. MATERIAL AND METHODS: The study included 13 patients with 22 lesions. The inclusion criteria were: patients with 1–4 inoperable liver lesions and absence of any extrahepatic disease. All but 3 patients received 3 fractions delivered by the Cyberknife system of a total of 45 grey (Gy). The other 3 patients received 30 Gy. RESULTS: The median follow-up time was 10.8 months (range: 7–16). The median dose was 41.5 Gy (range: 30–45). One lesion regressed (8%). In 5 patients, the disease was locally stabilized (38%), and in 7 other patients progression occurred (54%). Twelve patients (92%) are still alive, and 1 patient (8%) died. In 1 patient a new cancer (leukemia) was diagnosed. CONCLUSIONS: The SBRT is well tolerated and effective for local control of most liver malignant tumors. It appears that SBRT is best suited for those patients in whom systemic recurrence can be controlled by chemotherapy. Further studies are mandatory to elucidate these effects on tumors of varying histology and to elaborate upon criteria used to select patients who can benefit most from this treatment. Termedia Publishing House 2014-07-23 2014-12 /pmc/articles/PMC4280411/ /pubmed/25561987 http://dx.doi.org/10.5114/wiitm.2014.44258 Text en Copyright © 2014 Sekcja Wideochirurgii TChP http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
Frączek, Mariusz
Sobocki, Jacek
Pędziwiatr, Katarzyna
Skrocki, Edward
Piotrkowicz, Norbert
Tyc-Szczepaniak, Dobromira
Korab-Chrzanowska, Elżbieta
Hevelke, Piotr
Krasnodębski, Maciej
Koszewski, Waldemar
Robotic stereotactic body radiation therapy for liver-limited malignant tumors
title Robotic stereotactic body radiation therapy for liver-limited malignant tumors
title_full Robotic stereotactic body radiation therapy for liver-limited malignant tumors
title_fullStr Robotic stereotactic body radiation therapy for liver-limited malignant tumors
title_full_unstemmed Robotic stereotactic body radiation therapy for liver-limited malignant tumors
title_short Robotic stereotactic body radiation therapy for liver-limited malignant tumors
title_sort robotic stereotactic body radiation therapy for liver-limited malignant tumors
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280411/
https://www.ncbi.nlm.nih.gov/pubmed/25561987
http://dx.doi.org/10.5114/wiitm.2014.44258
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