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Aerobic Exercise Alleviates Ischemia-Induced Memory Impairment by Enhancing Cell Proliferation and Suppressing Neuronal Apoptosis in Hippocampus

PURPOSE: Neurogenic lower urinary tract dysfunction (NLUTD) is a possible consequence of several neurological disorders. NLUTD may produce debilitating symptoms and serious complications, such as chronic renal failure, and recurrent urinary tract infections. Many animal studies of NLUTD symptoms hav...

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Autores principales: Seo, Tae-Beom, Kim, Tae-Woon, Shin, Mal-Soon, Ji, Eun-Sang, Cho, Han-Sam, Lee, Jae-Min, Kim, Tae-Wook, Kim, Chang-Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Continence Society 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280438/
https://www.ncbi.nlm.nih.gov/pubmed/25562035
http://dx.doi.org/10.5213/inj.2014.18.4.187
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author Seo, Tae-Beom
Kim, Tae-Woon
Shin, Mal-Soon
Ji, Eun-Sang
Cho, Han-Sam
Lee, Jae-Min
Kim, Tae-Wook
Kim, Chang-Ju
author_facet Seo, Tae-Beom
Kim, Tae-Woon
Shin, Mal-Soon
Ji, Eun-Sang
Cho, Han-Sam
Lee, Jae-Min
Kim, Tae-Wook
Kim, Chang-Ju
author_sort Seo, Tae-Beom
collection PubMed
description PURPOSE: Neurogenic lower urinary tract dysfunction (NLUTD) is a possible consequence of several neurological disorders. NLUTD may produce debilitating symptoms and serious complications, such as chronic renal failure, and recurrent urinary tract infections. Many animal studies of NLUTD symptoms have focused on animal models of cerebral ischemia. In the present study, we investigated the effects of treadmill exercise on memory function and its relation to cell proliferation and apoptosis in the hippocampus, following transient global ischemia in gerbils. METHODS: To induce transient global ischemia in gerbil, both common carotid arteries were occluded for 5 minutes. Gerbils in the exercise groups were forced to run on a treadmill exercise for 30 minutes once a day for 2 weeks. Step-down avoidance task and Y maze task were performed. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL)-staining, immunohistochemistry for 5-bromo-2'-deoxyridine, doublecortin, caspase-3, and Western blot for brain-derived neurotrophic factor (BDNF), Bax, Bcl-2, cytochrome c, caspase-3 were conducted. RESULTS: Ischemia caused memory impairment with an increase of cell proliferation, BDNF expression, and apoptosis in the hippocampus. Treadmill exercise improved memory function with further increase of cell proliferation and BDNF expression and a decrease of apoptosis. CONCLUSIONS: The animal model that we have developed and our assessment of the relation between exercise and brain function can be useful tools for future investigations of NLUTD symptoms associated with stroke, particularly ischemic stroke. The present study suggests that treadmill exercise promoted the recovery of brain function after cerebral ischemia.
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spelling pubmed-42804382015-01-05 Aerobic Exercise Alleviates Ischemia-Induced Memory Impairment by Enhancing Cell Proliferation and Suppressing Neuronal Apoptosis in Hippocampus Seo, Tae-Beom Kim, Tae-Woon Shin, Mal-Soon Ji, Eun-Sang Cho, Han-Sam Lee, Jae-Min Kim, Tae-Wook Kim, Chang-Ju Int Neurourol J Original Article PURPOSE: Neurogenic lower urinary tract dysfunction (NLUTD) is a possible consequence of several neurological disorders. NLUTD may produce debilitating symptoms and serious complications, such as chronic renal failure, and recurrent urinary tract infections. Many animal studies of NLUTD symptoms have focused on animal models of cerebral ischemia. In the present study, we investigated the effects of treadmill exercise on memory function and its relation to cell proliferation and apoptosis in the hippocampus, following transient global ischemia in gerbils. METHODS: To induce transient global ischemia in gerbil, both common carotid arteries were occluded for 5 minutes. Gerbils in the exercise groups were forced to run on a treadmill exercise for 30 minutes once a day for 2 weeks. Step-down avoidance task and Y maze task were performed. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL)-staining, immunohistochemistry for 5-bromo-2'-deoxyridine, doublecortin, caspase-3, and Western blot for brain-derived neurotrophic factor (BDNF), Bax, Bcl-2, cytochrome c, caspase-3 were conducted. RESULTS: Ischemia caused memory impairment with an increase of cell proliferation, BDNF expression, and apoptosis in the hippocampus. Treadmill exercise improved memory function with further increase of cell proliferation and BDNF expression and a decrease of apoptosis. CONCLUSIONS: The animal model that we have developed and our assessment of the relation between exercise and brain function can be useful tools for future investigations of NLUTD symptoms associated with stroke, particularly ischemic stroke. The present study suggests that treadmill exercise promoted the recovery of brain function after cerebral ischemia. Korean Continence Society 2014-12 2014-12-29 /pmc/articles/PMC4280438/ /pubmed/25562035 http://dx.doi.org/10.5213/inj.2014.18.4.187 Text en Copyright © 2014 Korean Continence Society http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Seo, Tae-Beom
Kim, Tae-Woon
Shin, Mal-Soon
Ji, Eun-Sang
Cho, Han-Sam
Lee, Jae-Min
Kim, Tae-Wook
Kim, Chang-Ju
Aerobic Exercise Alleviates Ischemia-Induced Memory Impairment by Enhancing Cell Proliferation and Suppressing Neuronal Apoptosis in Hippocampus
title Aerobic Exercise Alleviates Ischemia-Induced Memory Impairment by Enhancing Cell Proliferation and Suppressing Neuronal Apoptosis in Hippocampus
title_full Aerobic Exercise Alleviates Ischemia-Induced Memory Impairment by Enhancing Cell Proliferation and Suppressing Neuronal Apoptosis in Hippocampus
title_fullStr Aerobic Exercise Alleviates Ischemia-Induced Memory Impairment by Enhancing Cell Proliferation and Suppressing Neuronal Apoptosis in Hippocampus
title_full_unstemmed Aerobic Exercise Alleviates Ischemia-Induced Memory Impairment by Enhancing Cell Proliferation and Suppressing Neuronal Apoptosis in Hippocampus
title_short Aerobic Exercise Alleviates Ischemia-Induced Memory Impairment by Enhancing Cell Proliferation and Suppressing Neuronal Apoptosis in Hippocampus
title_sort aerobic exercise alleviates ischemia-induced memory impairment by enhancing cell proliferation and suppressing neuronal apoptosis in hippocampus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280438/
https://www.ncbi.nlm.nih.gov/pubmed/25562035
http://dx.doi.org/10.5213/inj.2014.18.4.187
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