Long-Term Survival in a Case of Pleomorphic Carcinoma with a Brain Metastasis

Pleomorphic carcinoma (PC) is a rare malignant lung tumor with a poorer prognosis compared to other histological types of non-small cell lung cancer. However, several recent immunohistochemical studies revealed that a low MIB-1 index is a good prognostic marker in patients with PC. We report the cas...

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Autores principales: Yamanashi, Keiji, Marumo, Satoshi, Miura, Koki, Kawashima, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2014
Materias:
Published online: December, 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280452/
https://www.ncbi.nlm.nih.gov/pubmed/25566055
http://dx.doi.org/10.1159/000368186
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author Yamanashi, Keiji
Marumo, Satoshi
Miura, Koki
Kawashima, Masahiro
author_facet Yamanashi, Keiji
Marumo, Satoshi
Miura, Koki
Kawashima, Masahiro
author_sort Yamanashi, Keiji
collection PubMed
description Pleomorphic carcinoma (PC) is a rare malignant lung tumor with a poorer prognosis compared to other histological types of non-small cell lung cancer. However, several recent immunohistochemical studies revealed that a low MIB-1 index is a good prognostic marker in patients with PC. We report the case of a patient with PC and a single brain metastasis that achieved long-term recurrence-free survival following treatment with combined modality therapy. In this case, the MIB-1 index was reduced by gemcitabine-based chemotherapy, which may have led to long-term disease-free survival. The MIB-1 index may be a useful biomarker for the response to chemotherapy.
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spelling pubmed-42804522015-01-06 Long-Term Survival in a Case of Pleomorphic Carcinoma with a Brain Metastasis Yamanashi, Keiji Marumo, Satoshi Miura, Koki Kawashima, Masahiro Case Rep Oncol Published online: December, 2014 Pleomorphic carcinoma (PC) is a rare malignant lung tumor with a poorer prognosis compared to other histological types of non-small cell lung cancer. However, several recent immunohistochemical studies revealed that a low MIB-1 index is a good prognostic marker in patients with PC. We report the case of a patient with PC and a single brain metastasis that achieved long-term recurrence-free survival following treatment with combined modality therapy. In this case, the MIB-1 index was reduced by gemcitabine-based chemotherapy, which may have led to long-term disease-free survival. The MIB-1 index may be a useful biomarker for the response to chemotherapy. S. Karger AG 2014-12-02 /pmc/articles/PMC4280452/ /pubmed/25566055 http://dx.doi.org/10.1159/000368186 Text en Copyright © 2014 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: December, 2014
Yamanashi, Keiji
Marumo, Satoshi
Miura, Koki
Kawashima, Masahiro
Long-Term Survival in a Case of Pleomorphic Carcinoma with a Brain Metastasis
title Long-Term Survival in a Case of Pleomorphic Carcinoma with a Brain Metastasis
title_full Long-Term Survival in a Case of Pleomorphic Carcinoma with a Brain Metastasis
title_fullStr Long-Term Survival in a Case of Pleomorphic Carcinoma with a Brain Metastasis
title_full_unstemmed Long-Term Survival in a Case of Pleomorphic Carcinoma with a Brain Metastasis
title_short Long-Term Survival in a Case of Pleomorphic Carcinoma with a Brain Metastasis
title_sort long-term survival in a case of pleomorphic carcinoma with a brain metastasis
topic Published online: December, 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280452/
https://www.ncbi.nlm.nih.gov/pubmed/25566055
http://dx.doi.org/10.1159/000368186
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AT marumosatoshi longtermsurvivalinacaseofpleomorphiccarcinomawithabrainmetastasis
AT miurakoki longtermsurvivalinacaseofpleomorphiccarcinomawithabrainmetastasis
AT kawashimamasahiro longtermsurvivalinacaseofpleomorphiccarcinomawithabrainmetastasis

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