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New Thrombotic Events in Ischemic Stroke Patients with Elevated Factor VIII
Background. Heightened levels of Factor VIII (FVIII) have been associated with both arterial and venous thrombosis. While elevated FVIII is common during acute ischemic stroke (AIS), whether elevated FVIII confers an increased risk for recurrent thrombotic events (RTEs) following AIS has not been pr...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280494/ https://www.ncbi.nlm.nih.gov/pubmed/25580292 http://dx.doi.org/10.1155/2014/302861 |
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author | Gouse, Brittany M. Boehme, Amelia K. Monlezun, Dominique J. Siegler, James E. George, Alex J. Brag, Katherine Albright, Karen C. Beasley, T. Mark Leissinger, Cindy El Khoury, Ramy Martin-Schild, Sheryl |
author_facet | Gouse, Brittany M. Boehme, Amelia K. Monlezun, Dominique J. Siegler, James E. George, Alex J. Brag, Katherine Albright, Karen C. Beasley, T. Mark Leissinger, Cindy El Khoury, Ramy Martin-Schild, Sheryl |
author_sort | Gouse, Brittany M. |
collection | PubMed |
description | Background. Heightened levels of Factor VIII (FVIII) have been associated with both arterial and venous thrombosis. While elevated FVIII is common during acute ischemic stroke (AIS), whether elevated FVIII confers an increased risk for recurrent thrombotic events (RTEs) following AIS has not been previously explored. Methods. Consecutive AIS patients who presented to our center between July 2008 and September 2013 and had FVIII measured during admission were identified from our stroke registry. Baseline characteristics and the occurrence of RTE (recurrent or progressive ischemic stroke, DVT/PE, and MI) were compared in patients with and without elevated FVIII levels. Results. Of the 298 patients included, 203 (68.1%) had elevated FVIII levels. Patients with elevated FVIII had higher rates of any in-hospital RTE (18.7% versus 8.4%, P = 0.0218). This association remained after adjustment for baseline stroke severity and etiology (OR 1.01, 95% CI 1.00–1.01, P = 0.0013). Rates of major disability were also higher in patients who experienced a RTE (17.8% versus 3.2%, P < 0.0001). Conclusion. A significantly higher frequency of in-hospital RTEs occurred in AIS patients with elevated FVIII. The occurrence of such events was associated with higher morbidity. Further study is indicated to evaluate whether FVIII is a candidate biomarker for increased risk of RTEs following AIS. |
format | Online Article Text |
id | pubmed-4280494 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-42804942015-01-11 New Thrombotic Events in Ischemic Stroke Patients with Elevated Factor VIII Gouse, Brittany M. Boehme, Amelia K. Monlezun, Dominique J. Siegler, James E. George, Alex J. Brag, Katherine Albright, Karen C. Beasley, T. Mark Leissinger, Cindy El Khoury, Ramy Martin-Schild, Sheryl Thrombosis Research Article Background. Heightened levels of Factor VIII (FVIII) have been associated with both arterial and venous thrombosis. While elevated FVIII is common during acute ischemic stroke (AIS), whether elevated FVIII confers an increased risk for recurrent thrombotic events (RTEs) following AIS has not been previously explored. Methods. Consecutive AIS patients who presented to our center between July 2008 and September 2013 and had FVIII measured during admission were identified from our stroke registry. Baseline characteristics and the occurrence of RTE (recurrent or progressive ischemic stroke, DVT/PE, and MI) were compared in patients with and without elevated FVIII levels. Results. Of the 298 patients included, 203 (68.1%) had elevated FVIII levels. Patients with elevated FVIII had higher rates of any in-hospital RTE (18.7% versus 8.4%, P = 0.0218). This association remained after adjustment for baseline stroke severity and etiology (OR 1.01, 95% CI 1.00–1.01, P = 0.0013). Rates of major disability were also higher in patients who experienced a RTE (17.8% versus 3.2%, P < 0.0001). Conclusion. A significantly higher frequency of in-hospital RTEs occurred in AIS patients with elevated FVIII. The occurrence of such events was associated with higher morbidity. Further study is indicated to evaluate whether FVIII is a candidate biomarker for increased risk of RTEs following AIS. Hindawi Publishing Corporation 2014 2014-12-17 /pmc/articles/PMC4280494/ /pubmed/25580292 http://dx.doi.org/10.1155/2014/302861 Text en Copyright © 2014 Brittany M. Gouse et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Gouse, Brittany M. Boehme, Amelia K. Monlezun, Dominique J. Siegler, James E. George, Alex J. Brag, Katherine Albright, Karen C. Beasley, T. Mark Leissinger, Cindy El Khoury, Ramy Martin-Schild, Sheryl New Thrombotic Events in Ischemic Stroke Patients with Elevated Factor VIII |
title | New Thrombotic Events in Ischemic Stroke Patients with Elevated Factor VIII |
title_full | New Thrombotic Events in Ischemic Stroke Patients with Elevated Factor VIII |
title_fullStr | New Thrombotic Events in Ischemic Stroke Patients with Elevated Factor VIII |
title_full_unstemmed | New Thrombotic Events in Ischemic Stroke Patients with Elevated Factor VIII |
title_short | New Thrombotic Events in Ischemic Stroke Patients with Elevated Factor VIII |
title_sort | new thrombotic events in ischemic stroke patients with elevated factor viii |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280494/ https://www.ncbi.nlm.nih.gov/pubmed/25580292 http://dx.doi.org/10.1155/2014/302861 |
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