Hepatitis C Virus Life Cycle and Lipid Metabolism

Hepatitis C Virus (HCV) infects over 150 million people worldwide. In most cases HCV infection becomes chronic, causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma. HCV affects the cholesterol homeostasis and at the molecular level, every step of the virus life cycl...

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Autores principales: Popescu, Costin-Ioan, Riva, Laura, Vlaicu, Ovidiu, Farhat, Rayan, Rouillé, Yves, Dubuisson, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280516/
https://www.ncbi.nlm.nih.gov/pubmed/25517881
http://dx.doi.org/10.3390/biology3040892
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author Popescu, Costin-Ioan
Riva, Laura
Vlaicu, Ovidiu
Farhat, Rayan
Rouillé, Yves
Dubuisson, Jean
author_facet Popescu, Costin-Ioan
Riva, Laura
Vlaicu, Ovidiu
Farhat, Rayan
Rouillé, Yves
Dubuisson, Jean
author_sort Popescu, Costin-Ioan
collection PubMed
description Hepatitis C Virus (HCV) infects over 150 million people worldwide. In most cases HCV infection becomes chronic, causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma. HCV affects the cholesterol homeostasis and at the molecular level, every step of the virus life cycle is intimately connected to lipid metabolism. In this review, we present an update on the lipids and apolipoproteins that are involved in the HCV infectious cycle steps: entry, replication and assembly. Moreover, the result of the assembly process is a lipoviroparticle, which represents a peculiarity of hepatitis C virion. This review illustrates an example of an intricate virus-host interaction governed by lipid metabolism.
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spelling pubmed-42805162015-01-16 Hepatitis C Virus Life Cycle and Lipid Metabolism Popescu, Costin-Ioan Riva, Laura Vlaicu, Ovidiu Farhat, Rayan Rouillé, Yves Dubuisson, Jean Biology (Basel) Review Hepatitis C Virus (HCV) infects over 150 million people worldwide. In most cases HCV infection becomes chronic, causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma. HCV affects the cholesterol homeostasis and at the molecular level, every step of the virus life cycle is intimately connected to lipid metabolism. In this review, we present an update on the lipids and apolipoproteins that are involved in the HCV infectious cycle steps: entry, replication and assembly. Moreover, the result of the assembly process is a lipoviroparticle, which represents a peculiarity of hepatitis C virion. This review illustrates an example of an intricate virus-host interaction governed by lipid metabolism. MDPI 2014-12-15 /pmc/articles/PMC4280516/ /pubmed/25517881 http://dx.doi.org/10.3390/biology3040892 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Popescu, Costin-Ioan
Riva, Laura
Vlaicu, Ovidiu
Farhat, Rayan
Rouillé, Yves
Dubuisson, Jean
Hepatitis C Virus Life Cycle and Lipid Metabolism
title Hepatitis C Virus Life Cycle and Lipid Metabolism
title_full Hepatitis C Virus Life Cycle and Lipid Metabolism
title_fullStr Hepatitis C Virus Life Cycle and Lipid Metabolism
title_full_unstemmed Hepatitis C Virus Life Cycle and Lipid Metabolism
title_short Hepatitis C Virus Life Cycle and Lipid Metabolism
title_sort hepatitis c virus life cycle and lipid metabolism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280516/
https://www.ncbi.nlm.nih.gov/pubmed/25517881
http://dx.doi.org/10.3390/biology3040892
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AT rouilleyves hepatitiscviruslifecycleandlipidmetabolism
AT dubuissonjean hepatitiscviruslifecycleandlipidmetabolism

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