Constitutive ERK1/2 activation contributes to production of double minute chromosomes in tumour cells

Double minute chromosomes (DMs) are extrachromosomal cytogenetic structures found in tumour cells. As hallmarks of gene amplification, DMs often carry oncogenes and drug-resistance genes and play important roles in malignant tumour progression and drug resistance. The mitogen-activated protein kinas...

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Detalles Bibliográficos
Autores principales: Sun, Wenjing, Quan, Chao, Huang, Yun, Ji, Wei, Yu, Lisa, Li, Xinxin, Zhang, Yang, Zheng, Zhibo, Zou, Hongyan, Li, Quanxiao, Xu, Ping, Feng, Yan, Li, Li, Zhang, Yunyan, Cui, Yunfu, Jia, Xueyuan, Meng, Xiangning, Zhang, Chunyu, Jin, Yan, Bai, Jing, Yu, Jingcui, Yu, Yang, Yang, Jianhua, Fu, Songbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280677/
https://www.ncbi.nlm.nih.gov/pubmed/25214430
http://dx.doi.org/10.1002/path.4439

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