Frugal fat or munificent muscle: genomic imprinting and metabolism

Variation in body composition is a popular obsession. The culturally ‘ideal’ body type is light on fat and heavy on muscle but the human population is collectively laying on fat. A new study finds antagonistic effects of two imprinted genes, Grb10 and Dlk1, on body composition in mice. These finding...

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Detalles Bibliográficos
Autor principal: Haig, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280740/
https://www.ncbi.nlm.nih.gov/pubmed/25551395
http://dx.doi.org/10.1186/s12915-014-0104-2
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author Haig, David
author_facet Haig, David
author_sort Haig, David
collection PubMed
description Variation in body composition is a popular obsession. The culturally ‘ideal’ body type is light on fat and heavy on muscle but the human population is collectively laying on fat. A new study finds antagonistic effects of two imprinted genes, Grb10 and Dlk1, on body composition in mice. These findings pose the question whether there is an evolutionary conflict between genes of maternal and paternal origin over the optimal proportions of body fat and lean muscle mass. See research article: http://www.biomedcentral.com/1741-7007/12/99
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spelling pubmed-42807402015-01-01 Frugal fat or munificent muscle: genomic imprinting and metabolism Haig, David BMC Biol Commentary Variation in body composition is a popular obsession. The culturally ‘ideal’ body type is light on fat and heavy on muscle but the human population is collectively laying on fat. A new study finds antagonistic effects of two imprinted genes, Grb10 and Dlk1, on body composition in mice. These findings pose the question whether there is an evolutionary conflict between genes of maternal and paternal origin over the optimal proportions of body fat and lean muscle mass. See research article: http://www.biomedcentral.com/1741-7007/12/99 BioMed Central 2014-12-31 /pmc/articles/PMC4280740/ /pubmed/25551395 http://dx.doi.org/10.1186/s12915-014-0104-2 Text en © Haig; licensee BioMed Central. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Haig, David
Frugal fat or munificent muscle: genomic imprinting and metabolism
title Frugal fat or munificent muscle: genomic imprinting and metabolism
title_full Frugal fat or munificent muscle: genomic imprinting and metabolism
title_fullStr Frugal fat or munificent muscle: genomic imprinting and metabolism
title_full_unstemmed Frugal fat or munificent muscle: genomic imprinting and metabolism
title_short Frugal fat or munificent muscle: genomic imprinting and metabolism
title_sort frugal fat or munificent muscle: genomic imprinting and metabolism
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280740/
https://www.ncbi.nlm.nih.gov/pubmed/25551395
http://dx.doi.org/10.1186/s12915-014-0104-2
work_keys_str_mv AT haigdavid frugalfatormunificentmusclegenomicimprintingandmetabolism

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