Cargando…

Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides

The inhibition of insulin-regulated aminopeptidase (IRAP, EC 3.4.11.3) by angiotenesin IV is known to improve memory and learning in rats. Screening 10 500 low-molecular-weight compounds in an enzyme inhibition assay with IRAP from Chinese Hamster Ovary (CHO) cells provided an arylsulfonamide (N-(3-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Borhade, Sanjay R, Rosenström, Ulrika, Sävmarker, Jonas, Lundbäck, Thomas, Jenmalm-Jensen, Annika, Sigmundsson, Kristmundur, Axelsson, Hanna, Svensson, Fredrik, Konda, Vivek, Sköld, Christian, Larhed, Mats, Hallberg, Mathias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2014
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280825/ https://www.ncbi.nlm.nih.gov/pubmed/25558444 http://dx.doi.org/10.1002/open.201402027

Ejemplares similares

Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro‐Oxindole Dihydroquinazolinones as IRAP Inhibitors
por: Engen, Karin, et al.
Publicado: (2020)

Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides
por: Vanga, Sudarsana Reddy, et al.
Publicado: (2018)

From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase
por: Hallberg, Mathias, et al.
Publicado: (2020)

Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Benzopyran-Based Inhibitors
por: Vanga, Sudarsana Reddy, et al.
Publicado: (2021)

IRAP Inhibitors: M1-Aminopeptidase Family Inspiration
por: Barlow, Nicholas, et al.
Publicado: (2020)

Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures
por: Stam, Frida, et al.
Publicado: (2022)

The Discovery of Insulin-Regulated Aminopeptidase (IRAP) Inhibitors: A Literature Review
por: Georgiadis, Dimitris, et al.
Publicado: (2020)

Decarboxylative Palladium(II)-Catalyzed Synthesis of Aryl Amidines from Aryl Carboxylic Acids: Development and Mechanistic Investigation
por: Rydfjord, Jonas, et al.
Publicado: (2013)

S-acylation of the Insulin-Responsive Aminopeptidase (IRAP): Quantitative analysis and Identification of Modified Cysteines
por: Werno, Martin W., et al.
Publicado: (2015)

Temperature measurements with two different IR sensors in a continuous-flow microwave heated system
por: Rydfjord, Jonas, et al.
Publicado: (2013)

A PCR-RFLP method for detection of the LNPEP encoding human insulin-regulated aminopeptidase (IRAP) rs4869317 polymorphism
por: Ramírez-Expósito, María Jesús, et al.
Publicado: (2016)

Control of IFN-I responses by the aminopeptidase IRAP in neonatal C57BL/6 alveolar macrophages during RSV infection
por: Drajac, Carole, et al.
Publicado: (2021)

Discovery of Inhibitors of Insulin-Regulated Aminopeptidase as Cognitive Enhancers
por: Andersson, Hanna, et al.
Publicado: (2012)

Direct Palladium(II)-Catalyzed Synthesis of Arylamidines from Aryltrifluoroborates
por: Sävmarker, Jonas, et al.
Publicado: (2012)

Adipocyte-derived leucine aminopeptidase genotype and response to antihypertensive therapy
por: Hallberg, Par, et al.
Publicado: (2003)

Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide
por: Santamaria, Salvatore, et al.
Publicado: (2021)

Discovery of Dimeric Arylsulfonamides as Potent ADAM8 Inhibitors
por: Cuffaro, Doretta, et al.
Publicado: (2021)

Is There an Interplay Between the Functional Domains of IRAP?
por: Vear, Anika, et al.
Publicado: (2020)

Oxidative Heck Reactions using Aryltrifluoroborates and Aryl N-Methyliminodiacetic Acid (MIDA) Boronates
por: Sävmarker, Jonas, et al.
Publicado: (2012)

Comparative study of Dapagliflozin versus Glimepiride effect on insulin regulated aminopeptidase (IRAP) and interleukin-34 (IL-34) in patient with type 2 diabetes mellitus
por: Zekry, Rania, et al.
Publicado: (2023)

High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26
por: Mitran, Bogdan, et al.
Publicado: (2017)

Author Correction: Comparative study of Dapagliflozin versus Glimepiride effect on insulin regulated aminopeptidase (IRAP) and interleukin-34 (IL-34) in patient with type 2 diabetes mellitus
por: Zekry, Rania, et al.
Publicado: (2023)

Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer
por: Abouzayed, Ayman, et al.
Publicado: (2019)

Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas’ Disease
por: Lima, Marta L., et al.
Publicado: (2022)

Design, Synthesis, and Cytotoxic Activity of Novel Natural Arylsulfonamide-Inspired Molecules
por: Huang, Wenbo, et al.
Publicado: (2022)

Evaluation of the In Vitro Antifungal Activity of Novel Arylsulfonamides against Candida spp.
por: Ginestra, Giovanna, et al.
Publicado: (2023)

Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer—Optimization of the Affinity towards PSMA by Linker Modification in Murine Model
por: Lundmark, Fanny, et al.
Publicado: (2020)

iRAPs curb antisense transcription in E. coli
por: Magán, Andrés, et al.
Publicado: (2019)

IRAP Endosomes Control Phagosomal Maturation in Dendritic Cells
por: Weimershaus, Mirjana, et al.
Publicado: (2020)

Genetic diversity of Bletilla striata assessed by SCoT and IRAP markers
por: Guo, Yan, et al.
Publicado: (2018)

A third generation of radical fluorinating agents based on N-fluoro-N-arylsulfonamides
por: Meyer, Daniel, et al.
Publicado: (2018)

Novel Donepezil–Arylsulfonamide Hybrids as Multitarget-Directed Ligands for Potential Treatment of Alzheimer’s Disease
por: Queda, Fausto, et al.
Publicado: (2021)

In Silico Design, Synthesis, and Biological Evaluation of Anticancer Arylsulfonamide Endowed with Anti-Telomerase Activity
por: Culletta, Giulia, et al.
Publicado: (2022)

Bispecific GRPR-Antagonistic Anti-PSMA/GRPR Heterodimer for PET and SPECT Diagnostic Imaging of Prostate Cancer
por: Mitran, Bogdan, et al.
Publicado: (2019)

IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses
por: Evnouchidou, Irini, et al.
Publicado: (2020)

Enhanced recombinant expression and purification of human IRAP for biochemical and crystallography studies
por: Sui, Lufei, et al.
Publicado: (2021)

The CEACAM1 N-terminal Ig domain mediates cis- and trans-binding and is essential for allosteric rearrangements of CEACAM1 microclusters
por: Klaile, Esther, et al.
Publicado: (2009)

2nd International Symposium on Ionizing Radiation and Polymers : IRaP '96
por: Betz, N, et al.
Publicado: (1997)

Serum IRAP, a Novel Direct Biomarker of Prediabetes and Type 2 Diabetes?
por: Trocmé, Candice, et al.
Publicado: (2021)

Aminopeptidases
por: Sanz, Yolanda
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_ngb2e9crg02p3h68urrd9tdgu3