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O(6)-methylguanine-DNA methyltransferase activity is associated with response to alkylating agent therapy and with MGMT promoter methylation in glioblastoma and anaplastic glioma

BACKGROUND: CpG methylation in the O(6)-methylguanine-DNA methyltransferase (MGMT) promoter is associated with better outcome following alkylating agent chemotherapy in glioblastoma (GBM) and anaplastic glioma (AG). To what extent improved response reflects low or absent MGMT activity in glioma tiss...

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Detalles Bibliográficos
Autores principales:	Bobola, Michael S., Alnoor, Mohammad, Chen, John Y.-S., Kolstoe, Douglas D., Silbergeld, Daniel L., Rostomily, Robert C., Blank, A., Chamberlain, Marc C., Silber, John R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280839/ https://www.ncbi.nlm.nih.gov/pubmed/25558448 http://dx.doi.org/10.1016/j.bbacli.2014.11.003

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