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Metabolomic changes in patients with chronic obstructive pulmonary disease with abnormal Savda syndrome

The aim of this study was to determine the metabolic biomarkers for abnormal Savda syndrome in patients with chronic obstructive pulmonary disease (COPD). Based on Traditional Uyghur Medicine (TUM) theory, a total of 103 patients with COPD were classified into abnormal Savda and non-abnormal Savda s...

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Autores principales: XU, WEI-FANG, UPUR, HALMURAT, WU, YU-HUA, MAMTIMIN, BATUR, YANG, JIAN, GA, YONG-JUAN, YOU, LI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280916/
https://www.ncbi.nlm.nih.gov/pubmed/25574210
http://dx.doi.org/10.3892/etm.2014.2085
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author XU, WEI-FANG
UPUR, HALMURAT
WU, YU-HUA
MAMTIMIN, BATUR
YANG, JIAN
GA, YONG-JUAN
YOU, LI
author_facet XU, WEI-FANG
UPUR, HALMURAT
WU, YU-HUA
MAMTIMIN, BATUR
YANG, JIAN
GA, YONG-JUAN
YOU, LI
author_sort XU, WEI-FANG
collection PubMed
description The aim of this study was to determine the metabolic biomarkers for abnormal Savda syndrome in patients with chronic obstructive pulmonary disease (COPD). Based on Traditional Uyghur Medicine (TUM) theory, a total of 103 patients with COPD were classified into abnormal Savda and non-abnormal Savda syndrome groups and 52 healthy volunteers acted as the control group. Blood samples from the three groups were analyzed using nuclear magnetic resonance (NMR) spectroscopy combined with orthogonal projection to latent structure-discriminant analysis. NMR tests showed that the regional distributions of the patients with COPD with abnormal Savda syndrome, those with non-abnormal Savda syndrome and the control group were completely separate (P>0.05). The patients with COPD with abnormal Savda syndrome exhibited relatively low levels of amino acids, glycoproteins and unsaturated lipids (P<0.05) but significantly higher levels of lactic acid, carnitine, acetone and acetoacetate (P<0.05) compared with the healthy controls. Abnormal Savda syndrome was one of the main types of syndrome among the patients with COPD; increased age, a longer duration of illness and a higher disease severity were characteristic of this type of syndrome. In addition, the present study provided biochemical evidence for the TUM theory-based classification of patients with COPD; these biomarkers can be used in the clinic for the diagnosis of COPD with abnormal Savda syndrome. The study also demonstrated that the plasma metabolic disorder in patients with COPD with abnormal Savda syndrome was more serious than that in the control and COPD with non-abnormal Savda syndrome groups. The plasma metabolic disorder was also associated with a low immune function of the body and endocrine and energy metabolism disorders.
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spelling pubmed-42809162015-01-08 Metabolomic changes in patients with chronic obstructive pulmonary disease with abnormal Savda syndrome XU, WEI-FANG UPUR, HALMURAT WU, YU-HUA MAMTIMIN, BATUR YANG, JIAN GA, YONG-JUAN YOU, LI Exp Ther Med Articles The aim of this study was to determine the metabolic biomarkers for abnormal Savda syndrome in patients with chronic obstructive pulmonary disease (COPD). Based on Traditional Uyghur Medicine (TUM) theory, a total of 103 patients with COPD were classified into abnormal Savda and non-abnormal Savda syndrome groups and 52 healthy volunteers acted as the control group. Blood samples from the three groups were analyzed using nuclear magnetic resonance (NMR) spectroscopy combined with orthogonal projection to latent structure-discriminant analysis. NMR tests showed that the regional distributions of the patients with COPD with abnormal Savda syndrome, those with non-abnormal Savda syndrome and the control group were completely separate (P>0.05). The patients with COPD with abnormal Savda syndrome exhibited relatively low levels of amino acids, glycoproteins and unsaturated lipids (P<0.05) but significantly higher levels of lactic acid, carnitine, acetone and acetoacetate (P<0.05) compared with the healthy controls. Abnormal Savda syndrome was one of the main types of syndrome among the patients with COPD; increased age, a longer duration of illness and a higher disease severity were characteristic of this type of syndrome. In addition, the present study provided biochemical evidence for the TUM theory-based classification of patients with COPD; these biomarkers can be used in the clinic for the diagnosis of COPD with abnormal Savda syndrome. The study also demonstrated that the plasma metabolic disorder in patients with COPD with abnormal Savda syndrome was more serious than that in the control and COPD with non-abnormal Savda syndrome groups. The plasma metabolic disorder was also associated with a low immune function of the body and endocrine and energy metabolism disorders. D.A. Spandidos 2015-02 2014-11-24 /pmc/articles/PMC4280916/ /pubmed/25574210 http://dx.doi.org/10.3892/etm.2014.2085 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
XU, WEI-FANG
UPUR, HALMURAT
WU, YU-HUA
MAMTIMIN, BATUR
YANG, JIAN
GA, YONG-JUAN
YOU, LI
Metabolomic changes in patients with chronic obstructive pulmonary disease with abnormal Savda syndrome
title Metabolomic changes in patients with chronic obstructive pulmonary disease with abnormal Savda syndrome
title_full Metabolomic changes in patients with chronic obstructive pulmonary disease with abnormal Savda syndrome
title_fullStr Metabolomic changes in patients with chronic obstructive pulmonary disease with abnormal Savda syndrome
title_full_unstemmed Metabolomic changes in patients with chronic obstructive pulmonary disease with abnormal Savda syndrome
title_short Metabolomic changes in patients with chronic obstructive pulmonary disease with abnormal Savda syndrome
title_sort metabolomic changes in patients with chronic obstructive pulmonary disease with abnormal savda syndrome
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280916/
https://www.ncbi.nlm.nih.gov/pubmed/25574210
http://dx.doi.org/10.3892/etm.2014.2085
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