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Therapeutic potential of hepatocyte growth factor against cerebral ischemia (Review)
The effective treatment for cerebral ischemia has not yet been established. Hepatocyte growth factor (HGF) is a potent pleiotropic cytokine that is involved in cell and tissue regeneration, including in the central nervous system. Studies have demonstrated that an exogenous administration of HGF pro...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280917/ https://www.ncbi.nlm.nih.gov/pubmed/25574187 http://dx.doi.org/10.3892/etm.2014.2133 |
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author | ZENG, WEN JU, RONG MAO, MENG |
author_facet | ZENG, WEN JU, RONG MAO, MENG |
author_sort | ZENG, WEN |
collection | PubMed |
description | The effective treatment for cerebral ischemia has not yet been established. Hepatocyte growth factor (HGF) is a potent pleiotropic cytokine that is involved in cell and tissue regeneration, including in the central nervous system. Studies have demonstrated that an exogenous administration of HGF protects brain tissue from ischemic damage. In response to binding to the receptor c-Met, HGF activates the downstream signaling pathways (including the phosphatidylinositol 3-kinase/Akt, Ras/MAPK and signal transducer and activator of transcription pathways) which leads to various cellular responses involved in angiogenesis, glial scar formation, anti-apoptosis and neurogenesis. The purpose of this review is to summarize the present understanding of the therapeutic potential of HGF in cerebral ischemia. |
format | Online Article Text |
id | pubmed-4280917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-42809172015-01-08 Therapeutic potential of hepatocyte growth factor against cerebral ischemia (Review) ZENG, WEN JU, RONG MAO, MENG Exp Ther Med Articles The effective treatment for cerebral ischemia has not yet been established. Hepatocyte growth factor (HGF) is a potent pleiotropic cytokine that is involved in cell and tissue regeneration, including in the central nervous system. Studies have demonstrated that an exogenous administration of HGF protects brain tissue from ischemic damage. In response to binding to the receptor c-Met, HGF activates the downstream signaling pathways (including the phosphatidylinositol 3-kinase/Akt, Ras/MAPK and signal transducer and activator of transcription pathways) which leads to various cellular responses involved in angiogenesis, glial scar formation, anti-apoptosis and neurogenesis. The purpose of this review is to summarize the present understanding of the therapeutic potential of HGF in cerebral ischemia. D.A. Spandidos 2015-02 2014-12-15 /pmc/articles/PMC4280917/ /pubmed/25574187 http://dx.doi.org/10.3892/etm.2014.2133 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles ZENG, WEN JU, RONG MAO, MENG Therapeutic potential of hepatocyte growth factor against cerebral ischemia (Review) |
title | Therapeutic potential of hepatocyte growth factor against cerebral ischemia (Review) |
title_full | Therapeutic potential of hepatocyte growth factor against cerebral ischemia (Review) |
title_fullStr | Therapeutic potential of hepatocyte growth factor against cerebral ischemia (Review) |
title_full_unstemmed | Therapeutic potential of hepatocyte growth factor against cerebral ischemia (Review) |
title_short | Therapeutic potential of hepatocyte growth factor against cerebral ischemia (Review) |
title_sort | therapeutic potential of hepatocyte growth factor against cerebral ischemia (review) |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280917/ https://www.ncbi.nlm.nih.gov/pubmed/25574187 http://dx.doi.org/10.3892/etm.2014.2133 |
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