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Different levels of glycosylated hemoglobin influence severity and long-term prognosis of coronary heart disease patients with stent implantation

The aim of this study was to investigate the correlation between glycosylated hemoglobin (HbA1c) levels and the severity and long-term prognosis of coronary heart disease (CHD) with stent implantation. A total of 2,825 consecutive patients with stent implantation were stratified into three groups ba...

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Autores principales: WANG, JING, YAN, GAOLIANG, QIAO, YONG, WANG, DONG, MA, GENSHAN, TANG, CHENGCHUN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280935/
https://www.ncbi.nlm.nih.gov/pubmed/25574198
http://dx.doi.org/10.3892/etm.2014.2128
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author WANG, JING
YAN, GAOLIANG
QIAO, YONG
WANG, DONG
MA, GENSHAN
TANG, CHENGCHUN
author_facet WANG, JING
YAN, GAOLIANG
QIAO, YONG
WANG, DONG
MA, GENSHAN
TANG, CHENGCHUN
author_sort WANG, JING
collection PubMed
description The aim of this study was to investigate the correlation between glycosylated hemoglobin (HbA1c) levels and the severity and long-term prognosis of coronary heart disease (CHD) with stent implantation. A total of 2,825 consecutive patients with stent implantation were stratified into three groups based on the levels of HbA1c: Low HbA1c group (group A, HbA1c ≤5.9% or 41 mmol/mol; n=1,035), moderate HbA1c group (group B, 5.9%< HbA1c <6.8% or 41< HbAlc <51 mmol/mol; n=1,025) and high HbA1c group (group C, HbA1c ≥6.8% or 51 mmol/mol; n=765). The impact of HbA1c on the Gensini score and the long-term prognosis of CHD with stent implantation were observed. After an average of 1 year of follow-up of the 2,825 patients in a hospital cohort, participants with low or high HbA1c had a higher risk of major adverse cardiac events (MACE) and target lesion revascularization (TLR) compared with participants with moderate HbA1c after adjusting for multiple potential confounders (hazard ratios for low HbAlc, 1.505 and 1.478, respectively, and for high HbAlc, 1.626 and 1.522, respectively). Analysis of HbA1c as a continuous variable showed that each 1% increase of HbA1c was significantly associated with decreased risks of MACE and TLR of 53.5 and 54.2%, respectively, in those with a low HbA1c level and with increased risks of MACE and TLR of 9.5 and 9.2%, respectively, in those with a moderate or high HbA1c level, suggesting a U-shaped association between HbA1c and the risk of MACE and TLR. In conclusion, HbA1c levels, either as a continuous variable or a categorical variable, have a U-shaped correlation with MACE and TLR in CHD patients with stent implantation, even after adjustment for multiple confounders.
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spelling pubmed-42809352015-01-08 Different levels of glycosylated hemoglobin influence severity and long-term prognosis of coronary heart disease patients with stent implantation WANG, JING YAN, GAOLIANG QIAO, YONG WANG, DONG MA, GENSHAN TANG, CHENGCHUN Exp Ther Med Articles The aim of this study was to investigate the correlation between glycosylated hemoglobin (HbA1c) levels and the severity and long-term prognosis of coronary heart disease (CHD) with stent implantation. A total of 2,825 consecutive patients with stent implantation were stratified into three groups based on the levels of HbA1c: Low HbA1c group (group A, HbA1c ≤5.9% or 41 mmol/mol; n=1,035), moderate HbA1c group (group B, 5.9%< HbA1c <6.8% or 41< HbAlc <51 mmol/mol; n=1,025) and high HbA1c group (group C, HbA1c ≥6.8% or 51 mmol/mol; n=765). The impact of HbA1c on the Gensini score and the long-term prognosis of CHD with stent implantation were observed. After an average of 1 year of follow-up of the 2,825 patients in a hospital cohort, participants with low or high HbA1c had a higher risk of major adverse cardiac events (MACE) and target lesion revascularization (TLR) compared with participants with moderate HbA1c after adjusting for multiple potential confounders (hazard ratios for low HbAlc, 1.505 and 1.478, respectively, and for high HbAlc, 1.626 and 1.522, respectively). Analysis of HbA1c as a continuous variable showed that each 1% increase of HbA1c was significantly associated with decreased risks of MACE and TLR of 53.5 and 54.2%, respectively, in those with a low HbA1c level and with increased risks of MACE and TLR of 9.5 and 9.2%, respectively, in those with a moderate or high HbA1c level, suggesting a U-shaped association between HbA1c and the risk of MACE and TLR. In conclusion, HbA1c levels, either as a continuous variable or a categorical variable, have a U-shaped correlation with MACE and TLR in CHD patients with stent implantation, even after adjustment for multiple confounders. D.A. Spandidos 2015-02 2014-12-11 /pmc/articles/PMC4280935/ /pubmed/25574198 http://dx.doi.org/10.3892/etm.2014.2128 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
WANG, JING
YAN, GAOLIANG
QIAO, YONG
WANG, DONG
MA, GENSHAN
TANG, CHENGCHUN
Different levels of glycosylated hemoglobin influence severity and long-term prognosis of coronary heart disease patients with stent implantation
title Different levels of glycosylated hemoglobin influence severity and long-term prognosis of coronary heart disease patients with stent implantation
title_full Different levels of glycosylated hemoglobin influence severity and long-term prognosis of coronary heart disease patients with stent implantation
title_fullStr Different levels of glycosylated hemoglobin influence severity and long-term prognosis of coronary heart disease patients with stent implantation
title_full_unstemmed Different levels of glycosylated hemoglobin influence severity and long-term prognosis of coronary heart disease patients with stent implantation
title_short Different levels of glycosylated hemoglobin influence severity and long-term prognosis of coronary heart disease patients with stent implantation
title_sort different levels of glycosylated hemoglobin influence severity and long-term prognosis of coronary heart disease patients with stent implantation
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280935/
https://www.ncbi.nlm.nih.gov/pubmed/25574198
http://dx.doi.org/10.3892/etm.2014.2128
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