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Epistasis as a Determinant of the HIV-1 Protease's Robustness to Mutation
The robustness of phenotypes to mutation is critical to protein evolution; robustness may be an adaptive trait if it promotes evolution. We hypothesised that native proteins subjected to natural selection in vivo should be more robust than proteins generated in vitro in the absence of natural select...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281083/ https://www.ncbi.nlm.nih.gov/pubmed/25551558 http://dx.doi.org/10.1371/journal.pone.0116301 |