Optimization of Potent and Selective Quinazolinediones: Inhibitors of Respiratory Syncytial Virus That Block RNA-Dependent RNA-Polymerase Complex Activity

[Image: see text] A quinazolinedione-derived screening hit 2 was discovered with cellular antiviral activity against respiratory syncytial virus (CPE EC(50) = 2.1 μM), moderate efficacy in reducing viral progeny (4.2 log at 10 μM), and marginal cytotoxic liability (selectivity index, SI ∼ 24). Scaff...

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Detalles Bibliográficos
Autores principales: Matharu, Daljit S., Flaherty, Daniel P., Simpson, Denise S., Schroeder, Chad E., Chung, Donghoon, Yan, Dan, Noah, James W., Jonsson, Colleen B., White, E. Lucile, Aubé, Jeffrey, Plemper, Richard K., Severson, William E., Golden, Jennifer E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281105/
https://www.ncbi.nlm.nih.gov/pubmed/25399509
http://dx.doi.org/10.1021/jm500902x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281105/
https://www.ncbi.nlm.nih.gov/pubmed/25399509
http://dx.doi.org/10.1021/jm500902x

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