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A Comprehensive Expression Analysis of Mucins in Appendiceal Carcinoma in a Multicenter Study: MUC3 Is a Novel Prognostic Factor
BACKGROUND: Mucins are implicated in survival in various cancers, but there have been no report addressed on survival in appendiceal carcinoma, an uncommon disease with different clinical and pathological features from those of other colon cancers. We aimed to investigate the clinical implications o...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281150/ https://www.ncbi.nlm.nih.gov/pubmed/25551773 http://dx.doi.org/10.1371/journal.pone.0115613 |
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| author | Shibahara, Hiroaki Higashi, Michiyo Yokoyama, Seiya Rousseau, Karine Kitazono, Iwao Osako, Masahiko Shirahama, Hiroshi Tashiro, Yukie Kurumiya, Yasuhiro Narita, Michihiko Kuze, Shingo Hasagawa, Hiroshi Kato, Takehito Kubota, Hitoshi Suzuki, Hideaki Arai, Toshiyuki Sakai, Yu Yuasa, Norihiro Fujino, Masahiko Kondo, Shinji Okamoto, Yoshichika Yamamoto, Tatsuyoshi Hiromatsu, Takashi Sasaki, Eiji Shirai, Kazuhisa Kawai, Satoru Hattori, Koutarou Tsuji, Hideki Okochi, Osamu Sakamoto, Masaki Kondo, Akinobu Konishi, Naomi Batra, Surinder K. Yonezawa, Suguru |
| author_facet | Shibahara, Hiroaki Higashi, Michiyo Yokoyama, Seiya Rousseau, Karine Kitazono, Iwao Osako, Masahiko Shirahama, Hiroshi Tashiro, Yukie Kurumiya, Yasuhiro Narita, Michihiko Kuze, Shingo Hasagawa, Hiroshi Kato, Takehito Kubota, Hitoshi Suzuki, Hideaki Arai, Toshiyuki Sakai, Yu Yuasa, Norihiro Fujino, Masahiko Kondo, Shinji Okamoto, Yoshichika Yamamoto, Tatsuyoshi Hiromatsu, Takashi Sasaki, Eiji Shirai, Kazuhisa Kawai, Satoru Hattori, Koutarou Tsuji, Hideki Okochi, Osamu Sakamoto, Masaki Kondo, Akinobu Konishi, Naomi Batra, Surinder K. Yonezawa, Suguru |
| author_sort | Shibahara, Hiroaki |
| collection | PubMed |
| description | BACKGROUND: Mucins are implicated in survival in various cancers, but there have been no report addressed on survival in appendiceal carcinoma, an uncommon disease with different clinical and pathological features from those of other colon cancers. We aimed to investigate the clinical implications of expression of mucins in appendiceal carcinoma. METHODS: Expression profiles of MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC6, MUC16 and MUC17 in cancer tissue were examined by immunohistochemistry in 108 cases of surgically resected appendiceal carcinoma. RESULTS: The following relationships of mucins with clinicopathologic factors were identified: MUC1 with positive lymphatic invasion (p = 0.036); MUC2 with histological type (mucinous carcinoma, p<0.001), superficial invasion depth (p = 0.007), negative venous invasion (p = 0.003), and curative resection (p = 0.019); MUC3 with non-curative resection (p = 0.017); MUC5AC with histological type (mucinous carcinoma, p = 0.002), negative lymphatic invasion (p = 0.021), and negative venous invasion (p = 0.022); and MUC16 with positive lymph node metastasis (p = 0.035), positive venous invasion (p<0.05), and non-curative resection (p = 0.035). A poor prognosis was related to positive lymph node metastasis (p = 0.04), positive lymphatic invasion (p = 0.02), positive venous invasion (p<0.001), non-curative resection (p<0.001), and positive expression of MUC3 (p = 0.004). In multivariate analysis, positive venous invasion (HR: 6.93, 95% CI: 1.93–24.96, p = 0.003), non-curative resection (HR: 10.19, 95% CI: 3.05–34.07, p<0.001) and positive MUC3 expression (HR: 3.37, 95% CI: 1.13–10.03, p = 0.03) were identified as significant independent prognostic factors in patients with appendiceal carcinoma. CONCLUSIONS: Expression of MUC3 in appendiceal carcinoma is an independent factor for poor prognosis and a useful predictor of outcome in patients with appendiceal carcinoma after surgery. |
| format | Online Article Text |
| id | pubmed-4281150 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | Public Library of Science |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-42811502015-01-07 A Comprehensive Expression Analysis of Mucins in Appendiceal Carcinoma in a Multicenter Study: MUC3 Is a Novel Prognostic Factor Shibahara, Hiroaki Higashi, Michiyo Yokoyama, Seiya Rousseau, Karine Kitazono, Iwao Osako, Masahiko Shirahama, Hiroshi Tashiro, Yukie Kurumiya, Yasuhiro Narita, Michihiko Kuze, Shingo Hasagawa, Hiroshi Kato, Takehito Kubota, Hitoshi Suzuki, Hideaki Arai, Toshiyuki Sakai, Yu Yuasa, Norihiro Fujino, Masahiko Kondo, Shinji Okamoto, Yoshichika Yamamoto, Tatsuyoshi Hiromatsu, Takashi Sasaki, Eiji Shirai, Kazuhisa Kawai, Satoru Hattori, Koutarou Tsuji, Hideki Okochi, Osamu Sakamoto, Masaki Kondo, Akinobu Konishi, Naomi Batra, Surinder K. Yonezawa, Suguru PLoS One Research Article BACKGROUND: Mucins are implicated in survival in various cancers, but there have been no report addressed on survival in appendiceal carcinoma, an uncommon disease with different clinical and pathological features from those of other colon cancers. We aimed to investigate the clinical implications of expression of mucins in appendiceal carcinoma. METHODS: Expression profiles of MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC6, MUC16 and MUC17 in cancer tissue were examined by immunohistochemistry in 108 cases of surgically resected appendiceal carcinoma. RESULTS: The following relationships of mucins with clinicopathologic factors were identified: MUC1 with positive lymphatic invasion (p = 0.036); MUC2 with histological type (mucinous carcinoma, p<0.001), superficial invasion depth (p = 0.007), negative venous invasion (p = 0.003), and curative resection (p = 0.019); MUC3 with non-curative resection (p = 0.017); MUC5AC with histological type (mucinous carcinoma, p = 0.002), negative lymphatic invasion (p = 0.021), and negative venous invasion (p = 0.022); and MUC16 with positive lymph node metastasis (p = 0.035), positive venous invasion (p<0.05), and non-curative resection (p = 0.035). A poor prognosis was related to positive lymph node metastasis (p = 0.04), positive lymphatic invasion (p = 0.02), positive venous invasion (p<0.001), non-curative resection (p<0.001), and positive expression of MUC3 (p = 0.004). In multivariate analysis, positive venous invasion (HR: 6.93, 95% CI: 1.93–24.96, p = 0.003), non-curative resection (HR: 10.19, 95% CI: 3.05–34.07, p<0.001) and positive MUC3 expression (HR: 3.37, 95% CI: 1.13–10.03, p = 0.03) were identified as significant independent prognostic factors in patients with appendiceal carcinoma. CONCLUSIONS: Expression of MUC3 in appendiceal carcinoma is an independent factor for poor prognosis and a useful predictor of outcome in patients with appendiceal carcinoma after surgery. Public Library of Science 2014-12-31 /pmc/articles/PMC4281150/ /pubmed/25551773 http://dx.doi.org/10.1371/journal.pone.0115613 Text en © 2014 Shibahara et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| spellingShingle | Research Article Shibahara, Hiroaki Higashi, Michiyo Yokoyama, Seiya Rousseau, Karine Kitazono, Iwao Osako, Masahiko Shirahama, Hiroshi Tashiro, Yukie Kurumiya, Yasuhiro Narita, Michihiko Kuze, Shingo Hasagawa, Hiroshi Kato, Takehito Kubota, Hitoshi Suzuki, Hideaki Arai, Toshiyuki Sakai, Yu Yuasa, Norihiro Fujino, Masahiko Kondo, Shinji Okamoto, Yoshichika Yamamoto, Tatsuyoshi Hiromatsu, Takashi Sasaki, Eiji Shirai, Kazuhisa Kawai, Satoru Hattori, Koutarou Tsuji, Hideki Okochi, Osamu Sakamoto, Masaki Kondo, Akinobu Konishi, Naomi Batra, Surinder K. Yonezawa, Suguru A Comprehensive Expression Analysis of Mucins in Appendiceal Carcinoma in a Multicenter Study: MUC3 Is a Novel Prognostic Factor |
| title | A Comprehensive Expression Analysis of Mucins in Appendiceal Carcinoma in a Multicenter Study: MUC3 Is a Novel Prognostic Factor |
| title_full | A Comprehensive Expression Analysis of Mucins in Appendiceal Carcinoma in a Multicenter Study: MUC3 Is a Novel Prognostic Factor |
| title_fullStr | A Comprehensive Expression Analysis of Mucins in Appendiceal Carcinoma in a Multicenter Study: MUC3 Is a Novel Prognostic Factor |
| title_full_unstemmed | A Comprehensive Expression Analysis of Mucins in Appendiceal Carcinoma in a Multicenter Study: MUC3 Is a Novel Prognostic Factor |
| title_short | A Comprehensive Expression Analysis of Mucins in Appendiceal Carcinoma in a Multicenter Study: MUC3 Is a Novel Prognostic Factor |
| title_sort | comprehensive expression analysis of mucins in appendiceal carcinoma in a multicenter study: muc3 is a novel prognostic factor |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281150/ https://www.ncbi.nlm.nih.gov/pubmed/25551773 http://dx.doi.org/10.1371/journal.pone.0115613 |
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