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Midkine-Deficiency Delays Chondrogenesis during the Early Phase of Fracture Healing in Mice
The growth and differentiation factor midkine (Mdk) plays an important role in bone development and remodeling. Mdk-deficient mice display a high bone mass phenotype when aged 12 and 18 months. Furthermore, Mdk has been identified as a negative regulator of mechanically induced bone formation and it...
Autores principales: | Haffner-Luntzer, Melanie, Heilmann, Aline, Rapp, Anna Elise, Beie, Simon, Schinke, Thorsten, Amling, Michael, Ignatius, Anita, Liedert, Astrid |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281158/ https://www.ncbi.nlm.nih.gov/pubmed/25551381 http://dx.doi.org/10.1371/journal.pone.0116282 |
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