Interleukin-1β Enhances FasL-Induced Caspase-3/-7 Activity without Increasing Apoptosis in Primary Mouse Hepatocytes

Sustained inflammation may increase the susceptibility of hepatocytes to apoptotic cell death and therefore exacerbate liver damage. Here we report that the pro-inflammatory cytokine IL-1β sensitizes primary murine hepatocytes to Fas ligand (FasL)-induced caspase-3/-7 activity. This process was depe...

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Detalles Bibliográficos
Autores principales: Lutz, Anna, Sanwald, Julia, Thomas, Maria, Feuer, Ronny, Sawodny, Oliver, Ederer, Michael, Borner, Christoph, Humar, Matjaz, Merfort, Irmgard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281199/
https://www.ncbi.nlm.nih.gov/pubmed/25551609
http://dx.doi.org/10.1371/journal.pone.0115603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281199/
https://www.ncbi.nlm.nih.gov/pubmed/25551609
http://dx.doi.org/10.1371/journal.pone.0115603

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