Aurora-A kinase-inactive mutants disrupt the interaction with Ajuba and cause defects in mitotic spindle formation and G2/M phase arrest in HeLa cells

Aurora-A is a centrosome-localized serine/threonine kinase that is overexpressed in multiple human cancers. We previously reported an intramolecular inhibitory regulation of Aurora-A between its N-terminal regulatory domain (Nt, amino acids [aa] 1-128) and the C-terminal catalytic domain (Cd, aa 129...

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Detalles Bibliográficos
Autores principales: Bai, Meirong, Ni, Jun, Shen, Suqin, Huang, Qiang, Wu, Jiaxue, Le, Yichen, Yu, Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281342/
https://www.ncbi.nlm.nih.gov/pubmed/24499673
http://dx.doi.org/10.5483/BMBRep.2014.47.11.250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281342/
https://www.ncbi.nlm.nih.gov/pubmed/24499673
http://dx.doi.org/10.5483/BMBRep.2014.47.11.250

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