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A pharmacokinetic and pharmacodynamic investigation of Modufolin(®) compared to Isovorin(®) after single dose intravenous administration to patients with colon cancer: a randomized study
PURPOSE: Leucovorin is commonly used as folate supplement in 5-fluorouracil-based chemotherapy, but needs to be converted to active 5,10-methylenetetrahydrofolate (methyleneTHF) intracellularly. This provides for interindividual differences. MethyleneTHF has recently been developed into the stable,...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281361/ https://www.ncbi.nlm.nih.gov/pubmed/25342290 http://dx.doi.org/10.1007/s00280-014-2611-9 |