The Roles of CD147 and/or Cyclophilin A in Kidney Diseases

CD147 is a widely expressed integral plasma membrane glycoprotein and has been involved in a variety of physiological and pathological activities in combination with different partners, including cyclophilins, caveolin-1, monocarboxylate transporters, and integrins. Recent data demonstrate that both...

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Detalles Bibliográficos
Autores principales: Qu, Xin, Wang, Chunting, Zhang, Jicheng, Qie, Guoqiang, Zhou, Jianxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281390/
https://www.ncbi.nlm.nih.gov/pubmed/25580061
http://dx.doi.org/10.1155/2014/728673
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author Qu, Xin
Wang, Chunting
Zhang, Jicheng
Qie, Guoqiang
Zhou, Jianxin
author_facet Qu, Xin
Wang, Chunting
Zhang, Jicheng
Qie, Guoqiang
Zhou, Jianxin
author_sort Qu, Xin
collection PubMed
description CD147 is a widely expressed integral plasma membrane glycoprotein and has been involved in a variety of physiological and pathological activities in combination with different partners, including cyclophilins, caveolin-1, monocarboxylate transporters, and integrins. Recent data demonstrate that both CyPA and CD147 significantly contribute to renal inflammation, acute kidney injury, renal fibrosis, and renal cell carcinoma. Here we review the current understanding of cyclophilin A and CD147 expression and functions in kidney diseases and potential implications for treatment of kidney diseases.
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spelling pubmed-42813902015-01-11 The Roles of CD147 and/or Cyclophilin A in Kidney Diseases Qu, Xin Wang, Chunting Zhang, Jicheng Qie, Guoqiang Zhou, Jianxin Mediators Inflamm Review Article CD147 is a widely expressed integral plasma membrane glycoprotein and has been involved in a variety of physiological and pathological activities in combination with different partners, including cyclophilins, caveolin-1, monocarboxylate transporters, and integrins. Recent data demonstrate that both CyPA and CD147 significantly contribute to renal inflammation, acute kidney injury, renal fibrosis, and renal cell carcinoma. Here we review the current understanding of cyclophilin A and CD147 expression and functions in kidney diseases and potential implications for treatment of kidney diseases. Hindawi Publishing Corporation 2014 2014-12-17 /pmc/articles/PMC4281390/ /pubmed/25580061 http://dx.doi.org/10.1155/2014/728673 Text en Copyright © 2014 Xin Qu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Qu, Xin
Wang, Chunting
Zhang, Jicheng
Qie, Guoqiang
Zhou, Jianxin
The Roles of CD147 and/or Cyclophilin A in Kidney Diseases
title The Roles of CD147 and/or Cyclophilin A in Kidney Diseases
title_full The Roles of CD147 and/or Cyclophilin A in Kidney Diseases
title_fullStr The Roles of CD147 and/or Cyclophilin A in Kidney Diseases
title_full_unstemmed The Roles of CD147 and/or Cyclophilin A in Kidney Diseases
title_short The Roles of CD147 and/or Cyclophilin A in Kidney Diseases
title_sort roles of cd147 and/or cyclophilin a in kidney diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281390/
https://www.ncbi.nlm.nih.gov/pubmed/25580061
http://dx.doi.org/10.1155/2014/728673
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