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Zhichan powder regulates nigrostriatal dopamine synthesis and metabolism in Parkinson's disease rats☆
In this study, rat models of Parkinson’s disease induced by substantia nigra injection of 6-hydroxy-dopamine were intragastrically administered Zhichan powder daily for 50 days. Reverse transcription PCR results showed that tyrosine hydroxylase mRNA expression in the rat substantia nigra was signifi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281411/ https://www.ncbi.nlm.nih.gov/pubmed/25558223 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.27.004 |
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author | Zhou, Qingwei Chen, Jiajun Yi, Shihong Lou, Yongwei Tang, Weimin Liu, Yongmao Zhang, Pengguo |
author_facet | Zhou, Qingwei Chen, Jiajun Yi, Shihong Lou, Yongwei Tang, Weimin Liu, Yongmao Zhang, Pengguo |
author_sort | Zhou, Qingwei |
collection | PubMed |
description | In this study, rat models of Parkinson’s disease induced by substantia nigra injection of 6-hydroxy-dopamine were intragastrically administered Zhichan powder daily for 50 days. Reverse transcription PCR results showed that tyrosine hydroxylase mRNA expression in the rat substantia nigra was significantly increased, while monoamine oxidase B mRNA expression was significantly decreased in the Zhichan powder group, compared with the model group. In addition, the levels of striatal dopamine and homovanillic acid, the ratio of dopamine to homovanillic acid, and the activity of blood superoxide dismutase were all higher in the Zhichan powder group than in the model group, but the content of malondialdehyde in blood was lower. Our experimental findings indicate that Zhichan powder has an antioxidant effect, it can regulate the expression of monoamine oxidase B and tyrosine hydroxylase in the substantia nigra of Parkinson’s disease rats, and it can facilitate the secretion of striatal dopamine and its metabolite homovanillic acid. |
format | Online Article Text |
id | pubmed-4281411 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-42814112015-01-02 Zhichan powder regulates nigrostriatal dopamine synthesis and metabolism in Parkinson's disease rats☆ Zhou, Qingwei Chen, Jiajun Yi, Shihong Lou, Yongwei Tang, Weimin Liu, Yongmao Zhang, Pengguo Neural Regen Res Research and Report: Traditional Chinese Medicine and Neural Regeneration In this study, rat models of Parkinson’s disease induced by substantia nigra injection of 6-hydroxy-dopamine were intragastrically administered Zhichan powder daily for 50 days. Reverse transcription PCR results showed that tyrosine hydroxylase mRNA expression in the rat substantia nigra was significantly increased, while monoamine oxidase B mRNA expression was significantly decreased in the Zhichan powder group, compared with the model group. In addition, the levels of striatal dopamine and homovanillic acid, the ratio of dopamine to homovanillic acid, and the activity of blood superoxide dismutase were all higher in the Zhichan powder group than in the model group, but the content of malondialdehyde in blood was lower. Our experimental findings indicate that Zhichan powder has an antioxidant effect, it can regulate the expression of monoamine oxidase B and tyrosine hydroxylase in the substantia nigra of Parkinson’s disease rats, and it can facilitate the secretion of striatal dopamine and its metabolite homovanillic acid. Medknow Publications & Media Pvt Ltd 2012-09-25 /pmc/articles/PMC4281411/ /pubmed/25558223 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.27.004 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research and Report: Traditional Chinese Medicine and Neural Regeneration Zhou, Qingwei Chen, Jiajun Yi, Shihong Lou, Yongwei Tang, Weimin Liu, Yongmao Zhang, Pengguo Zhichan powder regulates nigrostriatal dopamine synthesis and metabolism in Parkinson's disease rats☆ |
title | Zhichan powder regulates nigrostriatal dopamine synthesis and metabolism in Parkinson's disease rats☆ |
title_full | Zhichan powder regulates nigrostriatal dopamine synthesis and metabolism in Parkinson's disease rats☆ |
title_fullStr | Zhichan powder regulates nigrostriatal dopamine synthesis and metabolism in Parkinson's disease rats☆ |
title_full_unstemmed | Zhichan powder regulates nigrostriatal dopamine synthesis and metabolism in Parkinson's disease rats☆ |
title_short | Zhichan powder regulates nigrostriatal dopamine synthesis and metabolism in Parkinson's disease rats☆ |
title_sort | zhichan powder regulates nigrostriatal dopamine synthesis and metabolism in parkinson's disease rats☆ |
topic | Research and Report: Traditional Chinese Medicine and Neural Regeneration |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281411/ https://www.ncbi.nlm.nih.gov/pubmed/25558223 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.27.004 |
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