A laminin 511 matrix is regulated by TAZ and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells

Understanding how the extracellular matrix impacts the function of cancer stem cells (CSCs) is a significant but poorly understood problem. We report that breast CSCs produce a laminin (LM) 511 matrix that promotes self-renewal and tumor initiation by engaging the α6Bβ1 integrin and activating the H...

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Autores principales: Chang, Cheng, Goel, Hira Lal, Gao, Huijie, Pursell, Bryan, Shultz, Leonard D., Greiner, Dale L., Ingerpuu, Sulev, Patarroyo, Manuel, Cao, Shiliang, Lim, Elgene, Mao, Junhao, McKee, Karen Kulju, Yurchenco, Peter D., Mercurio, Arthur M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281560/
https://www.ncbi.nlm.nih.gov/pubmed/25561492
http://dx.doi.org/10.1101/gad.253682.114
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author Chang, Cheng
Goel, Hira Lal
Gao, Huijie
Pursell, Bryan
Shultz, Leonard D.
Greiner, Dale L.
Ingerpuu, Sulev
Patarroyo, Manuel
Cao, Shiliang
Lim, Elgene
Mao, Junhao
McKee, Karen Kulju
Yurchenco, Peter D.
Mercurio, Arthur M.
author_facet Chang, Cheng
Goel, Hira Lal
Gao, Huijie
Pursell, Bryan
Shultz, Leonard D.
Greiner, Dale L.
Ingerpuu, Sulev
Patarroyo, Manuel
Cao, Shiliang
Lim, Elgene
Mao, Junhao
McKee, Karen Kulju
Yurchenco, Peter D.
Mercurio, Arthur M.
author_sort Chang, Cheng
collection PubMed
description Understanding how the extracellular matrix impacts the function of cancer stem cells (CSCs) is a significant but poorly understood problem. We report that breast CSCs produce a laminin (LM) 511 matrix that promotes self-renewal and tumor initiation by engaging the α6Bβ1 integrin and activating the Hippo transducer TAZ. Although TAZ is important for the function of breast CSCs, the mechanism is unknown. We observed that TAZ regulates the transcription of the α5 subunit of LM511 and the formation of a LM511 matrix. These data establish a positive feedback loop involving TAZ and LM511 that contributes to stemness in breast cancer.
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spelling pubmed-42815602015-07-01 A laminin 511 matrix is regulated by TAZ and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells Chang, Cheng Goel, Hira Lal Gao, Huijie Pursell, Bryan Shultz, Leonard D. Greiner, Dale L. Ingerpuu, Sulev Patarroyo, Manuel Cao, Shiliang Lim, Elgene Mao, Junhao McKee, Karen Kulju Yurchenco, Peter D. Mercurio, Arthur M. Genes Dev Research Communication Understanding how the extracellular matrix impacts the function of cancer stem cells (CSCs) is a significant but poorly understood problem. We report that breast CSCs produce a laminin (LM) 511 matrix that promotes self-renewal and tumor initiation by engaging the α6Bβ1 integrin and activating the Hippo transducer TAZ. Although TAZ is important for the function of breast CSCs, the mechanism is unknown. We observed that TAZ regulates the transcription of the α5 subunit of LM511 and the formation of a LM511 matrix. These data establish a positive feedback loop involving TAZ and LM511 that contributes to stemness in breast cancer. Cold Spring Harbor Laboratory Press 2015-01-01 /pmc/articles/PMC4281560/ /pubmed/25561492 http://dx.doi.org/10.1101/gad.253682.114 Text en © 2015 Chang et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Research Communication
Chang, Cheng
Goel, Hira Lal
Gao, Huijie
Pursell, Bryan
Shultz, Leonard D.
Greiner, Dale L.
Ingerpuu, Sulev
Patarroyo, Manuel
Cao, Shiliang
Lim, Elgene
Mao, Junhao
McKee, Karen Kulju
Yurchenco, Peter D.
Mercurio, Arthur M.
A laminin 511 matrix is regulated by TAZ and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells
title A laminin 511 matrix is regulated by TAZ and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells
title_full A laminin 511 matrix is regulated by TAZ and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells
title_fullStr A laminin 511 matrix is regulated by TAZ and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells
title_full_unstemmed A laminin 511 matrix is regulated by TAZ and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells
title_short A laminin 511 matrix is regulated by TAZ and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells
title_sort laminin 511 matrix is regulated by taz and functions as the ligand for the α6bβ1 integrin to sustain breast cancer stem cells
topic Research Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281560/
https://www.ncbi.nlm.nih.gov/pubmed/25561492
http://dx.doi.org/10.1101/gad.253682.114
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