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Clinical biomarkers in sickle cell disease
Sickle cell disease (SCD) is a hereditary blood disorder caused by a single gene. Various blood and urine biomarkers have been identified in SCD which are associated with laboratory and medical history. Biomarkers have been proven helpful in identifying different interconnected disease-causing mecha...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281636/ https://www.ncbi.nlm.nih.gov/pubmed/25561879 http://dx.doi.org/10.1016/j.sjbs.2014.09.005 |
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author | Damanhouri, Ghazi A. Jarullah, Jummanah Marouf, Samy Hindawi, S.I. Mushtaq, Gohar Kamal, Mohammad A. |
author_facet | Damanhouri, Ghazi A. Jarullah, Jummanah Marouf, Samy Hindawi, S.I. Mushtaq, Gohar Kamal, Mohammad A. |
author_sort | Damanhouri, Ghazi A. |
collection | PubMed |
description | Sickle cell disease (SCD) is a hereditary blood disorder caused by a single gene. Various blood and urine biomarkers have been identified in SCD which are associated with laboratory and medical history. Biomarkers have been proven helpful in identifying different interconnected disease-causing mechanisms of SCD, including hypercoagulability, hemolysis, inflammation, oxidative stress, vasculopathy, reperfusion injury and reduced vasodilatory responses in endothelium, to name just a few. However, there exists a need to establish a panel of validated blood and urine biomarkers in SCD. This paper reviews the current contribution of biochemical markers associated with clinical manifestation and identification of sub-phenotypes in SCD. |
format | Online Article Text |
id | pubmed-4281636 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
record_format | MEDLINE/PubMed |
spelling | pubmed-42816362015-01-05 Clinical biomarkers in sickle cell disease Damanhouri, Ghazi A. Jarullah, Jummanah Marouf, Samy Hindawi, S.I. Mushtaq, Gohar Kamal, Mohammad A. Saudi J Biol Sci Review Sickle cell disease (SCD) is a hereditary blood disorder caused by a single gene. Various blood and urine biomarkers have been identified in SCD which are associated with laboratory and medical history. Biomarkers have been proven helpful in identifying different interconnected disease-causing mechanisms of SCD, including hypercoagulability, hemolysis, inflammation, oxidative stress, vasculopathy, reperfusion injury and reduced vasodilatory responses in endothelium, to name just a few. However, there exists a need to establish a panel of validated blood and urine biomarkers in SCD. This paper reviews the current contribution of biochemical markers associated with clinical manifestation and identification of sub-phenotypes in SCD. 2014-09-18 2015-01 /pmc/articles/PMC4281636/ /pubmed/25561879 http://dx.doi.org/10.1016/j.sjbs.2014.09.005 Text en © 2015 King Saud University. Production and Hosting by Elsevier B.V. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
spellingShingle | Review Damanhouri, Ghazi A. Jarullah, Jummanah Marouf, Samy Hindawi, S.I. Mushtaq, Gohar Kamal, Mohammad A. Clinical biomarkers in sickle cell disease |
title | Clinical biomarkers in sickle cell disease |
title_full | Clinical biomarkers in sickle cell disease |
title_fullStr | Clinical biomarkers in sickle cell disease |
title_full_unstemmed | Clinical biomarkers in sickle cell disease |
title_short | Clinical biomarkers in sickle cell disease |
title_sort | clinical biomarkers in sickle cell disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281636/ https://www.ncbi.nlm.nih.gov/pubmed/25561879 http://dx.doi.org/10.1016/j.sjbs.2014.09.005 |
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