Efficacy of Recombinant Human Interleukin 7 in a Patient With Severe Lymphopenia-Related Progressive Multifocal Leukoencephalopathy

In this study, we report the case of a patient with profound lymphopenia after allogenic bone marrow transplantation who developed severe progressive multifocal leukoencephalopathy. Single-agent recombinant human interleukin-7 therapy was associated with restoration of anti-John Cunningham polyomavi...

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Autores principales: Gasnault, Jacques, de Goër de Herve, Marie-Ghislaine, Michot, Jean-Marie, Hendel-Chavez, Houria, Seta, Vannina, Mazet, Anne-Aurélie, Croughs, Thérèse, Stankoff, Bruno, Bourhis, Jean-Henri, Lambotte, Olivier, Delfraissy, Jean-François, Taoufik, Yassine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281783/
https://www.ncbi.nlm.nih.gov/pubmed/25734144
http://dx.doi.org/10.1093/ofid/ofu074
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author Gasnault, Jacques
de Goër de Herve, Marie-Ghislaine
Michot, Jean-Marie
Hendel-Chavez, Houria
Seta, Vannina
Mazet, Anne-Aurélie
Croughs, Thérèse
Stankoff, Bruno
Bourhis, Jean-Henri
Lambotte, Olivier
Delfraissy, Jean-François
Taoufik, Yassine
author_facet Gasnault, Jacques
de Goër de Herve, Marie-Ghislaine
Michot, Jean-Marie
Hendel-Chavez, Houria
Seta, Vannina
Mazet, Anne-Aurélie
Croughs, Thérèse
Stankoff, Bruno
Bourhis, Jean-Henri
Lambotte, Olivier
Delfraissy, Jean-François
Taoufik, Yassine
author_sort Gasnault, Jacques
collection PubMed
description In this study, we report the case of a patient with profound lymphopenia after allogenic bone marrow transplantation who developed severe progressive multifocal leukoencephalopathy. Single-agent recombinant human interleukin-7 therapy was associated with restoration of anti-John Cunningham polyomavirus (JCV) T-cell responses, JCV clearance from cerebrospinal fluid, and a dramatic clinical improvement.
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spelling pubmed-42817832015-03-02 Efficacy of Recombinant Human Interleukin 7 in a Patient With Severe Lymphopenia-Related Progressive Multifocal Leukoencephalopathy Gasnault, Jacques de Goër de Herve, Marie-Ghislaine Michot, Jean-Marie Hendel-Chavez, Houria Seta, Vannina Mazet, Anne-Aurélie Croughs, Thérèse Stankoff, Bruno Bourhis, Jean-Henri Lambotte, Olivier Delfraissy, Jean-François Taoufik, Yassine Open Forum Infect Dis Brief Reports In this study, we report the case of a patient with profound lymphopenia after allogenic bone marrow transplantation who developed severe progressive multifocal leukoencephalopathy. Single-agent recombinant human interleukin-7 therapy was associated with restoration of anti-John Cunningham polyomavirus (JCV) T-cell responses, JCV clearance from cerebrospinal fluid, and a dramatic clinical improvement. Oxford University Press 2014-08-26 /pmc/articles/PMC4281783/ /pubmed/25734144 http://dx.doi.org/10.1093/ofid/ofu074 Text en © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Reports
Gasnault, Jacques
de Goër de Herve, Marie-Ghislaine
Michot, Jean-Marie
Hendel-Chavez, Houria
Seta, Vannina
Mazet, Anne-Aurélie
Croughs, Thérèse
Stankoff, Bruno
Bourhis, Jean-Henri
Lambotte, Olivier
Delfraissy, Jean-François
Taoufik, Yassine
Efficacy of Recombinant Human Interleukin 7 in a Patient With Severe Lymphopenia-Related Progressive Multifocal Leukoencephalopathy
title Efficacy of Recombinant Human Interleukin 7 in a Patient With Severe Lymphopenia-Related Progressive Multifocal Leukoencephalopathy
title_full Efficacy of Recombinant Human Interleukin 7 in a Patient With Severe Lymphopenia-Related Progressive Multifocal Leukoencephalopathy
title_fullStr Efficacy of Recombinant Human Interleukin 7 in a Patient With Severe Lymphopenia-Related Progressive Multifocal Leukoencephalopathy
title_full_unstemmed Efficacy of Recombinant Human Interleukin 7 in a Patient With Severe Lymphopenia-Related Progressive Multifocal Leukoencephalopathy
title_short Efficacy of Recombinant Human Interleukin 7 in a Patient With Severe Lymphopenia-Related Progressive Multifocal Leukoencephalopathy
title_sort efficacy of recombinant human interleukin 7 in a patient with severe lymphopenia-related progressive multifocal leukoencephalopathy
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281783/
https://www.ncbi.nlm.nih.gov/pubmed/25734144
http://dx.doi.org/10.1093/ofid/ofu074
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