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Hepatitis C in Sub-Saharan Africa: Urgent Need for Attention
The hepatitis C virus (HCV), which was not recognized as an infectious agent until the 1980s, is responsible for a worldwide epidemic. The World Health Organization estimates global prevalence at 2.8%, with 185 million persons infected. In contrast to hepatitis B, where successful vaccine campaigns...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281810/ https://www.ncbi.nlm.nih.gov/pubmed/25734135 http://dx.doi.org/10.1093/ofid/ofu065 |
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author | Layden, Jennifer E. Phillips, Richard Opare-Sem, Ohene Akere, Adegboyega Salako, Babatunde L. Nelson, Kenrad Dugas, Lara Luke, Amy Tayo, Bamidele O. Cooper, Richard S. |
author_facet | Layden, Jennifer E. Phillips, Richard Opare-Sem, Ohene Akere, Adegboyega Salako, Babatunde L. Nelson, Kenrad Dugas, Lara Luke, Amy Tayo, Bamidele O. Cooper, Richard S. |
author_sort | Layden, Jennifer E. |
collection | PubMed |
description | The hepatitis C virus (HCV), which was not recognized as an infectious agent until the 1980s, is responsible for a worldwide epidemic. The World Health Organization estimates global prevalence at 2.8%, with 185 million persons infected. In contrast to hepatitis B, where successful vaccine campaigns have reduced the disease burden, much less progress has been made toward the control of HCV. Phylogenetic studies suggest that HCV originated in Africa and has been endemic in some regions for at least 500–600 years. However, little is known about the epidemiology, transmission, and clinical course of HCV in Africa. With the advent of highly effective anti-HCV agents, there exists great potential to at least curb the global epidemic. For regions such as sub-Saharan Africa, however, this will require a thorough understanding of the regional population-level epidemiology, risk factors, and transmission mechanisms. Only then can effective treatment and prevention strategies be introduced. |
format | Online Article Text |
id | pubmed-4281810 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-42818102015-03-02 Hepatitis C in Sub-Saharan Africa: Urgent Need for Attention Layden, Jennifer E. Phillips, Richard Opare-Sem, Ohene Akere, Adegboyega Salako, Babatunde L. Nelson, Kenrad Dugas, Lara Luke, Amy Tayo, Bamidele O. Cooper, Richard S. Open Forum Infect Dis Perspectives The hepatitis C virus (HCV), which was not recognized as an infectious agent until the 1980s, is responsible for a worldwide epidemic. The World Health Organization estimates global prevalence at 2.8%, with 185 million persons infected. In contrast to hepatitis B, where successful vaccine campaigns have reduced the disease burden, much less progress has been made toward the control of HCV. Phylogenetic studies suggest that HCV originated in Africa and has been endemic in some regions for at least 500–600 years. However, little is known about the epidemiology, transmission, and clinical course of HCV in Africa. With the advent of highly effective anti-HCV agents, there exists great potential to at least curb the global epidemic. For regions such as sub-Saharan Africa, however, this will require a thorough understanding of the regional population-level epidemiology, risk factors, and transmission mechanisms. Only then can effective treatment and prevention strategies be introduced. Oxford University Press 2014-09-17 /pmc/articles/PMC4281810/ /pubmed/25734135 http://dx.doi.org/10.1093/ofid/ofu065 Text en © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com. |
spellingShingle | Perspectives Layden, Jennifer E. Phillips, Richard Opare-Sem, Ohene Akere, Adegboyega Salako, Babatunde L. Nelson, Kenrad Dugas, Lara Luke, Amy Tayo, Bamidele O. Cooper, Richard S. Hepatitis C in Sub-Saharan Africa: Urgent Need for Attention |
title | Hepatitis C in Sub-Saharan Africa: Urgent Need for Attention |
title_full | Hepatitis C in Sub-Saharan Africa: Urgent Need for Attention |
title_fullStr | Hepatitis C in Sub-Saharan Africa: Urgent Need for Attention |
title_full_unstemmed | Hepatitis C in Sub-Saharan Africa: Urgent Need for Attention |
title_short | Hepatitis C in Sub-Saharan Africa: Urgent Need for Attention |
title_sort | hepatitis c in sub-saharan africa: urgent need for attention |
topic | Perspectives |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281810/ https://www.ncbi.nlm.nih.gov/pubmed/25734135 http://dx.doi.org/10.1093/ofid/ofu065 |
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