Strategic Targeting of Multiple Water‐Mediated Interactions: A Concise and Rational Structure‐Based Design Approach to Potent and Selective MMP‐13 Inhibitors

Water in the architecture of life: Potent and selective matrix metalloproteinase‐13 (MMP‐13) inhibitors were rationally designed by targeting multiple water‐mediated interactions between the target protein and small‐molecule inhibitors. This structure‐based design concept offers tremendous opportuni...

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Detalles Bibliográficos
Autores principales: Fischer, Thomas, Riedl, Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY‐VCH Verlag 2013
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281860/
https://www.ncbi.nlm.nih.gov/pubmed/23894097
http://dx.doi.org/10.1002/cmdc.201300278
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author Fischer, Thomas
Riedl, Rainer
author_facet Fischer, Thomas
Riedl, Rainer
author_sort Fischer, Thomas
collection PubMed
description Water in the architecture of life: Potent and selective matrix metalloproteinase‐13 (MMP‐13) inhibitors were rationally designed by targeting multiple water‐mediated interactions between the target protein and small‐molecule inhibitors. This structure‐based design concept offers tremendous opportunities for the discovery of unique small molecules with tailored biological activity.[Image: see text]
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spelling pubmed-42818602015-01-15 Strategic Targeting of Multiple Water‐Mediated Interactions: A Concise and Rational Structure‐Based Design Approach to Potent and Selective MMP‐13 Inhibitors Fischer, Thomas Riedl, Rainer ChemMedChem Communications Water in the architecture of life: Potent and selective matrix metalloproteinase‐13 (MMP‐13) inhibitors were rationally designed by targeting multiple water‐mediated interactions between the target protein and small‐molecule inhibitors. This structure‐based design concept offers tremendous opportunities for the discovery of unique small molecules with tailored biological activity.[Image: see text] WILEY‐VCH Verlag 2013-08-27 2013-07-26 /pmc/articles/PMC4281860/ /pubmed/23894097 http://dx.doi.org/10.1002/cmdc.201300278 Text en © 2013 The Authors. Published by Wiley‐VCH Verlag GmbH & Co. KGaA. https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Communications
Fischer, Thomas
Riedl, Rainer
Strategic Targeting of Multiple Water‐Mediated Interactions: A Concise and Rational Structure‐Based Design Approach to Potent and Selective MMP‐13 Inhibitors
title Strategic Targeting of Multiple Water‐Mediated Interactions: A Concise and Rational Structure‐Based Design Approach to Potent and Selective MMP‐13 Inhibitors
title_full Strategic Targeting of Multiple Water‐Mediated Interactions: A Concise and Rational Structure‐Based Design Approach to Potent and Selective MMP‐13 Inhibitors
title_fullStr Strategic Targeting of Multiple Water‐Mediated Interactions: A Concise and Rational Structure‐Based Design Approach to Potent and Selective MMP‐13 Inhibitors
title_full_unstemmed Strategic Targeting of Multiple Water‐Mediated Interactions: A Concise and Rational Structure‐Based Design Approach to Potent and Selective MMP‐13 Inhibitors
title_short Strategic Targeting of Multiple Water‐Mediated Interactions: A Concise and Rational Structure‐Based Design Approach to Potent and Selective MMP‐13 Inhibitors
title_sort strategic targeting of multiple water‐mediated interactions: a concise and rational structure‐based design approach to potent and selective mmp‐13 inhibitors
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281860/
https://www.ncbi.nlm.nih.gov/pubmed/23894097
http://dx.doi.org/10.1002/cmdc.201300278
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