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Strategic Targeting of Multiple Water‐Mediated Interactions: A Concise and Rational Structure‐Based Design Approach to Potent and Selective MMP‐13 Inhibitors

Water in the architecture of life: Potent and selective matrix metalloproteinase‐13 (MMP‐13) inhibitors were rationally designed by targeting multiple water‐mediated interactions between the target protein and small‐molecule inhibitors. This structure‐based design concept offers tremendous opportuni...

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Detalles Bibliográficos
Autores principales:	Fischer, Thomas, Riedl, Rainer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY‐VCH Verlag 2013
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281860/ https://www.ncbi.nlm.nih.gov/pubmed/23894097 http://dx.doi.org/10.1002/cmdc.201300278

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