Electron Cryo‐Microscopy of TPPS(4)⋅2HCl Tubes Reveals a Helical Organisation Explaining the Origin of their Chirality

A widely studied achiral porphyrin, which is highly soluble in aqueous solutions (TPPS(4)), is shown to self‐assemble into helical nanotubes. These were imaged by electron cryo‐microscopy and a state‐of‐the‐art image analysis allows building a map at ∼5 Å resolution, one of the highest obtained so f...

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Detalles Bibliográficos
Autores principales: Short, Judith M., Berriman, John A., Kübel, Christian, El‐Hachemi, Zoubir, Naubron, Jean‐Valère, Balaban, Teodor Silviu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY‐VCH Verlag 2013
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281918/
https://www.ncbi.nlm.nih.gov/pubmed/23908093
http://dx.doi.org/10.1002/cphc.201300606
Descripción
Sumario:A widely studied achiral porphyrin, which is highly soluble in aqueous solutions (TPPS(4)), is shown to self‐assemble into helical nanotubes. These were imaged by electron cryo‐microscopy and a state‐of‐the‐art image analysis allows building a map at ∼5 Å resolution, one of the highest obtained so far for molecular materials. The authors were able to trace the apparent symmetry breaking to existing nuclei in the “as received samples”, while carefully purified samples show that both handnesses occur in equal amounts.[Image: see text]

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