A 2-Pyridone-Amide Inhibitor Targets the Glucose Metabolism Pathway of Chlamydia trachomatis

In a screen for compounds that inhibit infectivity of the obligate intracellular pathogen Chlamydia trachomatis, we identified the 2-pyridone amide KSK120. A fluorescent KSK120 analogue was synthesized and observed to be associated with the C. trachomatis surface, suggesting that its target is bacte...

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Detalles Bibliográficos
Autores principales: Engström, Patrik, Krishnan, K. Syam, Ngyuen, Bidong D., Chorell, Erik, Normark, Johan, Silver, Jim, Bastidas, Robert J., Welch, Matthew D., Hultgren, Scott J., Wolf-Watz, Hans, Valdivia, Raphael H., Almqvist, Fredrik, Bergström, Sven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281921/
https://www.ncbi.nlm.nih.gov/pubmed/25550323
http://dx.doi.org/10.1128/mBio.02304-14

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