Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine

The presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial des...

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Detalles Bibliográficos
Autores principales: Hiley, Crispin, de Bruin, Elza C, McGranahan, Nicholas, Swanton, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281956/
https://www.ncbi.nlm.nih.gov/pubmed/25222836
http://dx.doi.org/10.1186/s13059-014-0453-8
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author Hiley, Crispin
de Bruin, Elza C
McGranahan, Nicholas
Swanton, Charles
author_facet Hiley, Crispin
de Bruin, Elza C
McGranahan, Nicholas
Swanton, Charles
author_sort Hiley, Crispin
collection PubMed
description The presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial design.
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spelling pubmed-42819562015-01-03 Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine Hiley, Crispin de Bruin, Elza C McGranahan, Nicholas Swanton, Charles Genome Biol Review The presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial design. BioMed Central 2014-08-27 2014 /pmc/articles/PMC4281956/ /pubmed/25222836 http://dx.doi.org/10.1186/s13059-014-0453-8 Text en © Hiley et al.; licensee BioMed Central 2014 The licensee has exclusive rights to distribute this article, in any medium, for 12 months following its publication. After this time, the article is available under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Hiley, Crispin
de Bruin, Elza C
McGranahan, Nicholas
Swanton, Charles
Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine
title Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine
title_full Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine
title_fullStr Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine
title_full_unstemmed Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine
title_short Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine
title_sort deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281956/
https://www.ncbi.nlm.nih.gov/pubmed/25222836
http://dx.doi.org/10.1186/s13059-014-0453-8
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