Two autopsy cases of severe fever with thrombocytopenia syndrome (SFTS) in Japan: A pathognomonic histological feature and unique complication of SFTS

We report two autopsy cases of severe fever with thrombocytopenia syndrome (SFTS) with a high fatality rate in aged Japanese patients. Both cases were caused by a tick-bite. The pathognomonic histological feature was necrotizing lymphadenitis of systemic lymphoid tissue with SFTS viruses and SFTSV-R...

Descripción completa

Detalles Bibliográficos
Autores principales: Hiraki, Tsubasa, Yoshimitsu, Makoto, Suzuki, Tadaki, Goto, Yuko, Higashi, Michiyo, Yokoyama, Seiya, Tabuchi, Tomohisa, Futatsuki, Takahiro, Nakamura, Kentaro, Hasegawa, Hideki, Saijo, Masayuki, Kakihana, Yasuyuki, Arima, Naomichi, Yonezawa, Suguru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282027/
https://www.ncbi.nlm.nih.gov/pubmed/25329676
http://dx.doi.org/10.1111/pin.12207
Descripción
Sumario:We report two autopsy cases of severe fever with thrombocytopenia syndrome (SFTS) with a high fatality rate in aged Japanese patients. Both cases were caused by a tick-bite. The pathognomonic histological feature was necrotizing lymphadenitis of systemic lymphoid tissue with SFTS viruses and SFTSV-RNA copies. Marked fungal infections were also observed in the lungs of both patients. Since cellular immune function may be suppressed in SFTS patients, physicians should be aware of possible fungal infections.

Ejemplares similares