Two autopsy cases of severe fever with thrombocytopenia syndrome (SFTS) in Japan: A pathognomonic histological feature and unique complication of SFTS

We report two autopsy cases of severe fever with thrombocytopenia syndrome (SFTS) with a high fatality rate in aged Japanese patients. Both cases were caused by a tick-bite. The pathognomonic histological feature was necrotizing lymphadenitis of systemic lymphoid tissue with SFTS viruses and SFTSV-R...

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Autores principales: Hiraki, Tsubasa, Yoshimitsu, Makoto, Suzuki, Tadaki, Goto, Yuko, Higashi, Michiyo, Yokoyama, Seiya, Tabuchi, Tomohisa, Futatsuki, Takahiro, Nakamura, Kentaro, Hasegawa, Hideki, Saijo, Masayuki, Kakihana, Yasuyuki, Arima, Naomichi, Yonezawa, Suguru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282027/
https://www.ncbi.nlm.nih.gov/pubmed/25329676
http://dx.doi.org/10.1111/pin.12207
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author Hiraki, Tsubasa
Yoshimitsu, Makoto
Suzuki, Tadaki
Goto, Yuko
Higashi, Michiyo
Yokoyama, Seiya
Tabuchi, Tomohisa
Futatsuki, Takahiro
Nakamura, Kentaro
Hasegawa, Hideki
Saijo, Masayuki
Kakihana, Yasuyuki
Arima, Naomichi
Yonezawa, Suguru
author_facet Hiraki, Tsubasa
Yoshimitsu, Makoto
Suzuki, Tadaki
Goto, Yuko
Higashi, Michiyo
Yokoyama, Seiya
Tabuchi, Tomohisa
Futatsuki, Takahiro
Nakamura, Kentaro
Hasegawa, Hideki
Saijo, Masayuki
Kakihana, Yasuyuki
Arima, Naomichi
Yonezawa, Suguru
author_sort Hiraki, Tsubasa
collection PubMed
description We report two autopsy cases of severe fever with thrombocytopenia syndrome (SFTS) with a high fatality rate in aged Japanese patients. Both cases were caused by a tick-bite. The pathognomonic histological feature was necrotizing lymphadenitis of systemic lymphoid tissue with SFTS viruses and SFTSV-RNA copies. Marked fungal infections were also observed in the lungs of both patients. Since cellular immune function may be suppressed in SFTS patients, physicians should be aware of possible fungal infections.
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spelling pubmed-42820272015-01-15 Two autopsy cases of severe fever with thrombocytopenia syndrome (SFTS) in Japan: A pathognomonic histological feature and unique complication of SFTS Hiraki, Tsubasa Yoshimitsu, Makoto Suzuki, Tadaki Goto, Yuko Higashi, Michiyo Yokoyama, Seiya Tabuchi, Tomohisa Futatsuki, Takahiro Nakamura, Kentaro Hasegawa, Hideki Saijo, Masayuki Kakihana, Yasuyuki Arima, Naomichi Yonezawa, Suguru Pathol Int Case Reports We report two autopsy cases of severe fever with thrombocytopenia syndrome (SFTS) with a high fatality rate in aged Japanese patients. Both cases were caused by a tick-bite. The pathognomonic histological feature was necrotizing lymphadenitis of systemic lymphoid tissue with SFTS viruses and SFTSV-RNA copies. Marked fungal infections were also observed in the lungs of both patients. Since cellular immune function may be suppressed in SFTS patients, physicians should be aware of possible fungal infections. BlackWell Publishing Ltd 2014-11 2014-10-20 /pmc/articles/PMC4282027/ /pubmed/25329676 http://dx.doi.org/10.1111/pin.12207 Text en © 2014 The Authors. Pathology International published by Japanese Society of Pathology and Wiley Publishing Asia Pty Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Hiraki, Tsubasa
Yoshimitsu, Makoto
Suzuki, Tadaki
Goto, Yuko
Higashi, Michiyo
Yokoyama, Seiya
Tabuchi, Tomohisa
Futatsuki, Takahiro
Nakamura, Kentaro
Hasegawa, Hideki
Saijo, Masayuki
Kakihana, Yasuyuki
Arima, Naomichi
Yonezawa, Suguru
Two autopsy cases of severe fever with thrombocytopenia syndrome (SFTS) in Japan: A pathognomonic histological feature and unique complication of SFTS
title Two autopsy cases of severe fever with thrombocytopenia syndrome (SFTS) in Japan: A pathognomonic histological feature and unique complication of SFTS
title_full Two autopsy cases of severe fever with thrombocytopenia syndrome (SFTS) in Japan: A pathognomonic histological feature and unique complication of SFTS
title_fullStr Two autopsy cases of severe fever with thrombocytopenia syndrome (SFTS) in Japan: A pathognomonic histological feature and unique complication of SFTS
title_full_unstemmed Two autopsy cases of severe fever with thrombocytopenia syndrome (SFTS) in Japan: A pathognomonic histological feature and unique complication of SFTS
title_short Two autopsy cases of severe fever with thrombocytopenia syndrome (SFTS) in Japan: A pathognomonic histological feature and unique complication of SFTS
title_sort two autopsy cases of severe fever with thrombocytopenia syndrome (sfts) in japan: a pathognomonic histological feature and unique complication of sfts
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282027/
https://www.ncbi.nlm.nih.gov/pubmed/25329676
http://dx.doi.org/10.1111/pin.12207
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