Use of a small molecule cell cycle inhibitor to control cell growth and improve specific productivity and product quality of recombinant proteins in CHO cell cultures

The continued need to improve therapeutic recombinant protein productivity has led to ongoing assessment of appropriate strategies in the biopharmaceutical industry to establish robust processes with optimized critical variables, that is, viable cell density (VCD) and specific productivity (product...

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Detalles Bibliográficos
Autores principales: Du, Zhimei, Treiber, David, McCarter, John D, Fomina-Yadlin, Dina, Saleem, Ramsey A, McCoy, Rebecca E, Zhang, Yuling, Tharmalingam, Tharmala, Leith, Matthew, Follstad, Brian D, Dell, Brad, Grisim, Brent, Zupke, Craig, Heath, Carole, Morris, Arvia E, Reddy, Pranhitha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282109/
https://www.ncbi.nlm.nih.gov/pubmed/25042542
http://dx.doi.org/10.1002/bit.25332

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