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Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?

Mesenchymal stem cells (MSCs) are an adult stromal cell population possessing potent differentiation capacity and a potential for use across major histocompatibility complex barriers. Although allogeneic MSCs have potent immunosuppressive properties, evidence also suggests that they elicit a weak al...

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Autores principales: Lohan, Paul, Coleman, Cynthia M, Murphy, J Mary, Griffin, Matthew D, Ritter, Thomas, Ryan, Aideen E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282147/
https://www.ncbi.nlm.nih.gov/pubmed/25158057
http://dx.doi.org/10.1186/scrt488
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author Lohan, Paul
Coleman, Cynthia M
Murphy, J Mary
Griffin, Matthew D
Ritter, Thomas
Ryan, Aideen E
author_facet Lohan, Paul
Coleman, Cynthia M
Murphy, J Mary
Griffin, Matthew D
Ritter, Thomas
Ryan, Aideen E
author_sort Lohan, Paul
collection PubMed
description Mesenchymal stem cells (MSCs) are an adult stromal cell population possessing potent differentiation capacity and a potential for use across major histocompatibility complex barriers. Although allogeneic MSCs have potent immunosuppressive properties, evidence also suggests that they elicit a weak allogeneic immune response. However, the effect of induced differentiation on the immunosuppressive ability and immunogenicity of allogeneic MSCs is a potential obstacle when applying MSCs in tissue replacement therapies. These concerns will be explored in this review, with particular emphasis on changes in the cell surface expression of immunogenic markers, changes in the secretion of immunosuppressive molecules and in vivo functional benefits of the cell therapy. We review the literature from a translational point of view, focusing on pre-clinical studies that have utilised and analysed the effects of allogeneic immune responses on the ability of allogeneic MSCs to regenerate damaged tissue in models of bone, heart and cartilage defects.
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spelling pubmed-42821472015-01-03 Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned? Lohan, Paul Coleman, Cynthia M Murphy, J Mary Griffin, Matthew D Ritter, Thomas Ryan, Aideen E Stem Cell Res Ther Review Mesenchymal stem cells (MSCs) are an adult stromal cell population possessing potent differentiation capacity and a potential for use across major histocompatibility complex barriers. Although allogeneic MSCs have potent immunosuppressive properties, evidence also suggests that they elicit a weak allogeneic immune response. However, the effect of induced differentiation on the immunosuppressive ability and immunogenicity of allogeneic MSCs is a potential obstacle when applying MSCs in tissue replacement therapies. These concerns will be explored in this review, with particular emphasis on changes in the cell surface expression of immunogenic markers, changes in the secretion of immunosuppressive molecules and in vivo functional benefits of the cell therapy. We review the literature from a translational point of view, focusing on pre-clinical studies that have utilised and analysed the effects of allogeneic immune responses on the ability of allogeneic MSCs to regenerate damaged tissue in models of bone, heart and cartilage defects. BioMed Central 2014-08-19 /pmc/articles/PMC4282147/ /pubmed/25158057 http://dx.doi.org/10.1186/scrt488 Text en © The Author(s) 2014 This article is published under license to BioMed Central Ltd. The licensee has exclusive rights to distribute this article, in any medium, for 12 months following its publication. After this time, the article is available under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Lohan, Paul
Coleman, Cynthia M
Murphy, J Mary
Griffin, Matthew D
Ritter, Thomas
Ryan, Aideen E
Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?
title Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?
title_full Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?
title_fullStr Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?
title_full_unstemmed Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?
title_short Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?
title_sort changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282147/
https://www.ncbi.nlm.nih.gov/pubmed/25158057
http://dx.doi.org/10.1186/scrt488
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