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Influencing the secretion of myogenic factors from mesenchymal stem cells
Mounting evidence indicates that the regenerative effect of mesenchymal stem cells in skeletal muscle is related to the secretion of factors that stimulate resident myogenic cells. However, the environmental cues that affect the secreted factors of mesenchymal stem cells are not well understood. A r...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282150/ https://www.ncbi.nlm.nih.gov/pubmed/25157834 http://dx.doi.org/10.1186/scrt485 |
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author | Smith, Lucas R |
author_facet | Smith, Lucas R |
author_sort | Smith, Lucas R |
collection | PubMed |
description | Mounting evidence indicates that the regenerative effect of mesenchymal stem cells in skeletal muscle is related to the secretion of factors that stimulate resident myogenic cells. However, the environmental cues that affect the secreted factors of mesenchymal stem cells are not well understood. A recent publication demonstrated that secretion of factors is dependent on cell substrate, with mesenchymal stem cells grown on laminin providing more pro-myogenic factors than those grown on collagen, and that cellular strain may also play a role. Conditioned media from mesenchymal stem cells grown on laminin and subjected to strain provided the quickest and largest stimulation to myogenic cell proliferation. The influence of cell substrate and mechanical perturbation on mesenchymal stem cells therefore appears key to secretion of factors that support myogenesis. |
format | Online Article Text |
id | pubmed-4282150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-42821502015-01-03 Influencing the secretion of myogenic factors from mesenchymal stem cells Smith, Lucas R Stem Cell Res Ther Commentary Mounting evidence indicates that the regenerative effect of mesenchymal stem cells in skeletal muscle is related to the secretion of factors that stimulate resident myogenic cells. However, the environmental cues that affect the secreted factors of mesenchymal stem cells are not well understood. A recent publication demonstrated that secretion of factors is dependent on cell substrate, with mesenchymal stem cells grown on laminin providing more pro-myogenic factors than those grown on collagen, and that cellular strain may also play a role. Conditioned media from mesenchymal stem cells grown on laminin and subjected to strain provided the quickest and largest stimulation to myogenic cell proliferation. The influence of cell substrate and mechanical perturbation on mesenchymal stem cells therefore appears key to secretion of factors that support myogenesis. BioMed Central 2014-08-13 /pmc/articles/PMC4282150/ /pubmed/25157834 http://dx.doi.org/10.1186/scrt485 Text en © The Author(s) 2014 This article is published under license to BioMed Central Ltd. The licensee has exclusive rights to distribute this article, in any medium, for 12 months following its publication. After this time, the article is available under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Commentary Smith, Lucas R Influencing the secretion of myogenic factors from mesenchymal stem cells |
title | Influencing the secretion of myogenic factors from mesenchymal stem cells |
title_full | Influencing the secretion of myogenic factors from mesenchymal stem cells |
title_fullStr | Influencing the secretion of myogenic factors from mesenchymal stem cells |
title_full_unstemmed | Influencing the secretion of myogenic factors from mesenchymal stem cells |
title_short | Influencing the secretion of myogenic factors from mesenchymal stem cells |
title_sort | influencing the secretion of myogenic factors from mesenchymal stem cells |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282150/ https://www.ncbi.nlm.nih.gov/pubmed/25157834 http://dx.doi.org/10.1186/scrt485 |
work_keys_str_mv | AT smithlucasr influencingthesecretionofmyogenicfactorsfrommesenchymalstemcells |