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Modulation of Neural Circuit Actvity by Ethanol in Basolateral Amygdala
Ethanol actions in the amygdala formation may underlie in part the reinforcing effects of ethanol consumption. Previously a physiological phenomenon in the basolateral amygdala (BLA) that is dependent on neuronal network activity, compound postsynaptic potentials (cPSPs) were characterized. Effects...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society of Developmental Biology
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282243/ https://www.ncbi.nlm.nih.gov/pubmed/25949099 http://dx.doi.org/10.12717/DR.2012.16.4.265 |
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author | Chung, Leeyup |
author_facet | Chung, Leeyup |
author_sort | Chung, Leeyup |
collection | PubMed |
description | Ethanol actions in the amygdala formation may underlie in part the reinforcing effects of ethanol consumption. Previously a physiological phenomenon in the basolateral amygdala (BLA) that is dependent on neuronal network activity, compound postsynaptic potentials (cPSPs) were characterized. Effects of acute ethanol application on the frequency of cPSPs were subsequently investigated. Whole cell patch clamp recordings were performed from identified projection neurons in a rat brain slice preparation containing the amygdala formation. Acute ethanol exposure had complex effects on cPSP frequency, with both increases and decreases dependent on concentration, duration of exposure and age of the animal. Ethanol produces complex biphasic effects on synaptically-driven network activity in the BLA. These findings may relate to subjective effects of ethanol on arousal and anxiolysis in humans. |
format | Online Article Text |
id | pubmed-4282243 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Korean Society of Developmental Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-42822432015-05-06 Modulation of Neural Circuit Actvity by Ethanol in Basolateral Amygdala Chung, Leeyup Dev Reprod Article Ethanol actions in the amygdala formation may underlie in part the reinforcing effects of ethanol consumption. Previously a physiological phenomenon in the basolateral amygdala (BLA) that is dependent on neuronal network activity, compound postsynaptic potentials (cPSPs) were characterized. Effects of acute ethanol application on the frequency of cPSPs were subsequently investigated. Whole cell patch clamp recordings were performed from identified projection neurons in a rat brain slice preparation containing the amygdala formation. Acute ethanol exposure had complex effects on cPSP frequency, with both increases and decreases dependent on concentration, duration of exposure and age of the animal. Ethanol produces complex biphasic effects on synaptically-driven network activity in the BLA. These findings may relate to subjective effects of ethanol on arousal and anxiolysis in humans. Korean Society of Developmental Biology 2012-12 /pmc/articles/PMC4282243/ /pubmed/25949099 http://dx.doi.org/10.12717/DR.2012.16.4.265 Text en © Korean Society of Developmental Biology. All Rights Reserved http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Chung, Leeyup Modulation of Neural Circuit Actvity by Ethanol in Basolateral Amygdala |
title | Modulation of Neural Circuit Actvity by Ethanol in Basolateral Amygdala |
title_full | Modulation of Neural Circuit Actvity by Ethanol in Basolateral Amygdala |
title_fullStr | Modulation of Neural Circuit Actvity by Ethanol in Basolateral Amygdala |
title_full_unstemmed | Modulation of Neural Circuit Actvity by Ethanol in Basolateral Amygdala |
title_short | Modulation of Neural Circuit Actvity by Ethanol in Basolateral Amygdala |
title_sort | modulation of neural circuit actvity by ethanol in basolateral amygdala |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282243/ https://www.ncbi.nlm.nih.gov/pubmed/25949099 http://dx.doi.org/10.12717/DR.2012.16.4.265 |
work_keys_str_mv | AT chungleeyup modulationofneuralcircuitactvitybyethanolinbasolateralamygdala |