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Are power calculations useful? A multicentre neuroimaging study

There are now many reports of imaging experiments with small cohorts of typical participants that precede large‐scale, often multicentre studies of psychiatric and neurological disorders. Data from these calibration experiments are sufficient to make estimates of statistical power and predictions of...

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Autores principales: Suckling, John, Henty, Julian, Ecker, Christine, Deoni, Sean C., Lombardo, Michael V., Baron‐Cohen, Simon, Jezzard, Peter, Barnes, Anna, Chakrabarti, Bhismadev, Ooi, Cinly, Lai, Meng‐Chuan, Williams, Steven C., Murphy, Declan G.M., Bullmore, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282319/
https://www.ncbi.nlm.nih.gov/pubmed/24644267
http://dx.doi.org/10.1002/hbm.22465
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author Suckling, John
Henty, Julian
Ecker, Christine
Deoni, Sean C.
Lombardo, Michael V.
Baron‐Cohen, Simon
Jezzard, Peter
Barnes, Anna
Chakrabarti, Bhismadev
Ooi, Cinly
Lai, Meng‐Chuan
Williams, Steven C.
Murphy, Declan G.M.
Bullmore, Edward
author_facet Suckling, John
Henty, Julian
Ecker, Christine
Deoni, Sean C.
Lombardo, Michael V.
Baron‐Cohen, Simon
Jezzard, Peter
Barnes, Anna
Chakrabarti, Bhismadev
Ooi, Cinly
Lai, Meng‐Chuan
Williams, Steven C.
Murphy, Declan G.M.
Bullmore, Edward
author_sort Suckling, John
collection PubMed
description There are now many reports of imaging experiments with small cohorts of typical participants that precede large‐scale, often multicentre studies of psychiatric and neurological disorders. Data from these calibration experiments are sufficient to make estimates of statistical power and predictions of sample size and minimum observable effect sizes. In this technical note, we suggest how previously reported voxel‐based power calculations can support decision making in the design, execution and analysis of cross‐sectional multicentre imaging studies. The choice of MRI acquisition sequence, distribution of recruitment across acquisition centres, and changes to the registration method applied during data analysis are considered as examples. The consequences of modification are explored in quantitative terms by assessing the impact on sample size for a fixed effect size and detectable effect size for a fixed sample size. The calibration experiment dataset used for illustration was a precursor to the now complete Medical Research Council Autism Imaging Multicentre Study (MRC‐AIMS). Validation of the voxel‐based power calculations is made by comparing the predicted values from the calibration experiment with those observed in MRC‐AIMS. The effect of non‐linear mappings during image registration to a standard stereotactic space on the prediction is explored with reference to the amount of local deformation. In summary, power calculations offer a validated, quantitative means of making informed choices on important factors that influence the outcome of studies that consume significant resources. Hum Brain Mapp 35:3569–3577, 2014. © 2014 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc.
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spelling pubmed-42823192015-01-15 Are power calculations useful? A multicentre neuroimaging study Suckling, John Henty, Julian Ecker, Christine Deoni, Sean C. Lombardo, Michael V. Baron‐Cohen, Simon Jezzard, Peter Barnes, Anna Chakrabarti, Bhismadev Ooi, Cinly Lai, Meng‐Chuan Williams, Steven C. Murphy, Declan G.M. Bullmore, Edward Hum Brain Mapp Technical Report There are now many reports of imaging experiments with small cohorts of typical participants that precede large‐scale, often multicentre studies of psychiatric and neurological disorders. Data from these calibration experiments are sufficient to make estimates of statistical power and predictions of sample size and minimum observable effect sizes. In this technical note, we suggest how previously reported voxel‐based power calculations can support decision making in the design, execution and analysis of cross‐sectional multicentre imaging studies. The choice of MRI acquisition sequence, distribution of recruitment across acquisition centres, and changes to the registration method applied during data analysis are considered as examples. The consequences of modification are explored in quantitative terms by assessing the impact on sample size for a fixed effect size and detectable effect size for a fixed sample size. The calibration experiment dataset used for illustration was a precursor to the now complete Medical Research Council Autism Imaging Multicentre Study (MRC‐AIMS). Validation of the voxel‐based power calculations is made by comparing the predicted values from the calibration experiment with those observed in MRC‐AIMS. The effect of non‐linear mappings during image registration to a standard stereotactic space on the prediction is explored with reference to the amount of local deformation. In summary, power calculations offer a validated, quantitative means of making informed choices on important factors that influence the outcome of studies that consume significant resources. Hum Brain Mapp 35:3569–3577, 2014. © 2014 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc. John Wiley and Sons Inc. 2014-02-19 /pmc/articles/PMC4282319/ /pubmed/24644267 http://dx.doi.org/10.1002/hbm.22465 Text en Copyright © 2014 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/3.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Technical Report
Suckling, John
Henty, Julian
Ecker, Christine
Deoni, Sean C.
Lombardo, Michael V.
Baron‐Cohen, Simon
Jezzard, Peter
Barnes, Anna
Chakrabarti, Bhismadev
Ooi, Cinly
Lai, Meng‐Chuan
Williams, Steven C.
Murphy, Declan G.M.
Bullmore, Edward
Are power calculations useful? A multicentre neuroimaging study
title Are power calculations useful? A multicentre neuroimaging study
title_full Are power calculations useful? A multicentre neuroimaging study
title_fullStr Are power calculations useful? A multicentre neuroimaging study
title_full_unstemmed Are power calculations useful? A multicentre neuroimaging study
title_short Are power calculations useful? A multicentre neuroimaging study
title_sort are power calculations useful? a multicentre neuroimaging study
topic Technical Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282319/
https://www.ncbi.nlm.nih.gov/pubmed/24644267
http://dx.doi.org/10.1002/hbm.22465
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