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Are power calculations useful? A multicentre neuroimaging study
There are now many reports of imaging experiments with small cohorts of typical participants that precede large‐scale, often multicentre studies of psychiatric and neurological disorders. Data from these calibration experiments are sufficient to make estimates of statistical power and predictions of...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282319/ https://www.ncbi.nlm.nih.gov/pubmed/24644267 http://dx.doi.org/10.1002/hbm.22465 |
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author | Suckling, John Henty, Julian Ecker, Christine Deoni, Sean C. Lombardo, Michael V. Baron‐Cohen, Simon Jezzard, Peter Barnes, Anna Chakrabarti, Bhismadev Ooi, Cinly Lai, Meng‐Chuan Williams, Steven C. Murphy, Declan G.M. Bullmore, Edward |
author_facet | Suckling, John Henty, Julian Ecker, Christine Deoni, Sean C. Lombardo, Michael V. Baron‐Cohen, Simon Jezzard, Peter Barnes, Anna Chakrabarti, Bhismadev Ooi, Cinly Lai, Meng‐Chuan Williams, Steven C. Murphy, Declan G.M. Bullmore, Edward |
author_sort | Suckling, John |
collection | PubMed |
description | There are now many reports of imaging experiments with small cohorts of typical participants that precede large‐scale, often multicentre studies of psychiatric and neurological disorders. Data from these calibration experiments are sufficient to make estimates of statistical power and predictions of sample size and minimum observable effect sizes. In this technical note, we suggest how previously reported voxel‐based power calculations can support decision making in the design, execution and analysis of cross‐sectional multicentre imaging studies. The choice of MRI acquisition sequence, distribution of recruitment across acquisition centres, and changes to the registration method applied during data analysis are considered as examples. The consequences of modification are explored in quantitative terms by assessing the impact on sample size for a fixed effect size and detectable effect size for a fixed sample size. The calibration experiment dataset used for illustration was a precursor to the now complete Medical Research Council Autism Imaging Multicentre Study (MRC‐AIMS). Validation of the voxel‐based power calculations is made by comparing the predicted values from the calibration experiment with those observed in MRC‐AIMS. The effect of non‐linear mappings during image registration to a standard stereotactic space on the prediction is explored with reference to the amount of local deformation. In summary, power calculations offer a validated, quantitative means of making informed choices on important factors that influence the outcome of studies that consume significant resources. Hum Brain Mapp 35:3569–3577, 2014. © 2014 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc. |
format | Online Article Text |
id | pubmed-4282319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-42823192015-01-15 Are power calculations useful? A multicentre neuroimaging study Suckling, John Henty, Julian Ecker, Christine Deoni, Sean C. Lombardo, Michael V. Baron‐Cohen, Simon Jezzard, Peter Barnes, Anna Chakrabarti, Bhismadev Ooi, Cinly Lai, Meng‐Chuan Williams, Steven C. Murphy, Declan G.M. Bullmore, Edward Hum Brain Mapp Technical Report There are now many reports of imaging experiments with small cohorts of typical participants that precede large‐scale, often multicentre studies of psychiatric and neurological disorders. Data from these calibration experiments are sufficient to make estimates of statistical power and predictions of sample size and minimum observable effect sizes. In this technical note, we suggest how previously reported voxel‐based power calculations can support decision making in the design, execution and analysis of cross‐sectional multicentre imaging studies. The choice of MRI acquisition sequence, distribution of recruitment across acquisition centres, and changes to the registration method applied during data analysis are considered as examples. The consequences of modification are explored in quantitative terms by assessing the impact on sample size for a fixed effect size and detectable effect size for a fixed sample size. The calibration experiment dataset used for illustration was a precursor to the now complete Medical Research Council Autism Imaging Multicentre Study (MRC‐AIMS). Validation of the voxel‐based power calculations is made by comparing the predicted values from the calibration experiment with those observed in MRC‐AIMS. The effect of non‐linear mappings during image registration to a standard stereotactic space on the prediction is explored with reference to the amount of local deformation. In summary, power calculations offer a validated, quantitative means of making informed choices on important factors that influence the outcome of studies that consume significant resources. Hum Brain Mapp 35:3569–3577, 2014. © 2014 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc. John Wiley and Sons Inc. 2014-02-19 /pmc/articles/PMC4282319/ /pubmed/24644267 http://dx.doi.org/10.1002/hbm.22465 Text en Copyright © 2014 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/3.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Technical Report Suckling, John Henty, Julian Ecker, Christine Deoni, Sean C. Lombardo, Michael V. Baron‐Cohen, Simon Jezzard, Peter Barnes, Anna Chakrabarti, Bhismadev Ooi, Cinly Lai, Meng‐Chuan Williams, Steven C. Murphy, Declan G.M. Bullmore, Edward Are power calculations useful? A multicentre neuroimaging study |
title | Are power calculations useful? A multicentre neuroimaging study |
title_full | Are power calculations useful? A multicentre neuroimaging study |
title_fullStr | Are power calculations useful? A multicentre neuroimaging study |
title_full_unstemmed | Are power calculations useful? A multicentre neuroimaging study |
title_short | Are power calculations useful? A multicentre neuroimaging study |
title_sort | are power calculations useful? a multicentre neuroimaging study |
topic | Technical Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282319/ https://www.ncbi.nlm.nih.gov/pubmed/24644267 http://dx.doi.org/10.1002/hbm.22465 |
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