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Review: The genetics of Alzheimer's disease; putting flesh on the bones
For two decades the search for genes involved in Alzheimer's disease brought little reward; it was not until the advent of genome-wide association studies (GWAS) that genetic associations started to be revealed. Since 2009 increasingly large GWAS have revealed 20 loci, which in itself is a subs...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BlackWell Publishing Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282344/ https://www.ncbi.nlm.nih.gov/pubmed/24443964 http://dx.doi.org/10.1111/nan.12101 |
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author | Medway, C Morgan, K |
author_facet | Medway, C Morgan, K |
author_sort | Medway, C |
collection | PubMed |
description | For two decades the search for genes involved in Alzheimer's disease brought little reward; it was not until the advent of genome-wide association studies (GWAS) that genetic associations started to be revealed. Since 2009 increasingly large GWAS have revealed 20 loci, which in itself is a substantial increase in our understanding, but perhaps the more important feature is that these studies have highlighted novel pathways that are potentially involved in the disease process. This commentary assembles our latest knowledge while acknowledging that the casual functional variants, and undoubtedly, other genes are still yet to be discovered. This is the challenge that remains and the promise of next-generation sequencing is anticipated as there are a number of large initiatives which themselves should start to yield information before long. |
format | Online Article Text |
id | pubmed-4282344 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BlackWell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-42823442015-01-15 Review: The genetics of Alzheimer's disease; putting flesh on the bones Medway, C Morgan, K Neuropathol Appl Neurobiol Review Article For two decades the search for genes involved in Alzheimer's disease brought little reward; it was not until the advent of genome-wide association studies (GWAS) that genetic associations started to be revealed. Since 2009 increasingly large GWAS have revealed 20 loci, which in itself is a substantial increase in our understanding, but perhaps the more important feature is that these studies have highlighted novel pathways that are potentially involved in the disease process. This commentary assembles our latest knowledge while acknowledging that the casual functional variants, and undoubtedly, other genes are still yet to be discovered. This is the challenge that remains and the promise of next-generation sequencing is anticipated as there are a number of large initiatives which themselves should start to yield information before long. BlackWell Publishing Ltd 2014-02 2014-01-21 /pmc/articles/PMC4282344/ /pubmed/24443964 http://dx.doi.org/10.1111/nan.12101 Text en © 2013 The Authors. Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd on behalf of British Neuropathological Society. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Article Medway, C Morgan, K Review: The genetics of Alzheimer's disease; putting flesh on the bones |
title | Review: The genetics of Alzheimer's disease; putting flesh on the bones |
title_full | Review: The genetics of Alzheimer's disease; putting flesh on the bones |
title_fullStr | Review: The genetics of Alzheimer's disease; putting flesh on the bones |
title_full_unstemmed | Review: The genetics of Alzheimer's disease; putting flesh on the bones |
title_short | Review: The genetics of Alzheimer's disease; putting flesh on the bones |
title_sort | review: the genetics of alzheimer's disease; putting flesh on the bones |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282344/ https://www.ncbi.nlm.nih.gov/pubmed/24443964 http://dx.doi.org/10.1111/nan.12101 |
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